Peer-Reviewed Papers
2024
Fields, C., and Levin, M. (2024), Snakes and ladders in the evolution of language, Physics of Life Reviews, 2024 doi:10.1016/j.plrev.2024.04.007
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Pio-Lopez, L., Levin, M. (2024), Aging as a loss of morphostatic information: a developmental bioelectricity perspective, Ageing Research Reviews, 2024, 102310
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Balasubramanian, S., Weston, D., Levin, M., Davidian, D. C. C. (2024), Electroceuticals: emerging applications beyond the nervous system and excitable tissues, Cell Press, 2024, 2109
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Li, H., Yang, H.-Y., Asefifeyzabadi, N., Baniya, P., Medina Lopez, A., Gallegos, A., Zhu, K., Hsieh, H.-C., Nguyen, T., Hernandez, C., Zlobina, K., Recendez, C., Tebyani, M., Carrión, H., Selberg, J., Luo, L., Alhamo, M. A., Soulika, A. M., Levin, M., Norouzi, N., Gomez, M., Zhao, M., Teodorescu, M., Isseroff, R. R., Rolandi, M. (2024), Programmable delivery of fluoxetine via wearable bioelectronics for wound healing in vivo, bioRxiv, 2024, 2301115
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Balasubramanian, S., Weston, D., Levin, M., Davidian, D. C. C. (2024), Charging Ahead: Examining the future therapeutic potential of electroceuticals, Advanced Therapeutics, 2024, 2300344
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Fields, C., Glazebrook, J. F., and Levin, M. (2024), Principled Limitations on Self-Representation for Generic Physical Systems, Entropy, 26(3): 194
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Etcheverry, M., Moulin-Frier, C., Oudeyer, P.-Y, and Levin, M. (2024), AI-driven Automated Discovery Tools Reveal Diverse Behavioral Competencies of Biological Networks, eLife, 13: RP92683
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Tung, A., Sperry, M., Clawson, W., Pavuluri, A., Bulatao, S., Yue, M., Flores, R. M., Pai, V. McMillen, P., Kuchling, F., and Levin, M. (2024), Embryos assist morphogenesis of others through calcium and ATP signaling mechanisms in collective teratogen resistance, Nature Communications, 15(1): 535
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McMillen, P., and Levin, M. (2024), Optical Estimation of Bioelectric Patterns in Living Embryos, in M. Bizzarri (ed.), Systems Biology: Methods in Molecular Biology, 2745: 91-102, doi:10.1007/978-1-0716-3577-3_6
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Seifert, G., Sealander, A., Marzen, S., and Levin, M. (2024), From reinforcement learning to agency: Frameworks for understanding basal cognition, BioSystems, 235(1): 105107
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2023
Ciaunica, A., Levin, M., Rosas, F. E., and Friston, K. (2023), Nested Selves: Self-Organization and Shared Markov Blankets in Prenatal Development in Humans, Topics in Cognitive Science, in press, doi:10.1111/tops.12717
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Manicka, S., Pai, V. P, and Levin, M. (2023), Information integration during bioelectric regulation of morphogenesis of the embryonic frog brain, iScience, 26(12): 108398
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Rouleau, N., and Levin, M. (2023), The Multiple Realizability of Sentience in Living Systems and Beyond, eNeuro, 10(11), doi:10.1523/eneuro.0375-23.2023
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Blattner, M., and Levin, M. (2023) Long Range Communication via Gap Junctions and Stress in Planarian Morphogenesis: A Computational Study, Bioelectricity, 5(3): 196-209
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Mathews, J., and Levin, M. (2023) Cancer’s unique bioelectric properties: from cells to body-wide networks, Comment on: “The distinguishing electrical properties of cancer cells” by Elisabetta Di Gregorio, Simone Israel, Michael Staelens, Gabriella Tankel, Karthik Shankar, and Jack A. Tuszynski, Physics of Life Reviews, 47: 113-115
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Dungan, J., Mathews, J., Levin, M., and Koomson, V. (2023), Optimization of Oligomer Stamping Technique for Normally Closed Elastomeric Valves on Glass Substrate, Micromachines, 14(9): 1659
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Levin, M. (2023), Collective Intelligence of Morphogenesis as a Teleonomic Process, in Corning, P. A., Kauffman, S. A., Noble, D., Shapiro, J. A., Vane-Wright, R. I. Pross, A. (Eds.), Evolution "On Purpose": Teleonomy in Living Systems, The MIT Press: Cambridge, MA, 175-197
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Grodstein, J., McMillen, P., and Levin, M. (2023), Closing the Loop on Morphogenesis: A Mathematical Model of Morphogenesis by Closed-Loop Reaction-Diffusion, Frontiers in Cell and Developmental Biology, 11: 1087650
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Cervera, J., Levin, M., and Mafé, S. (2023), Correcting instructive electric potential patterns in multicellular systems: External actions and endogenous processes, Biochimica et Biophysica Acta (BBA) - General Subjects, 1867(10): 130440
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Welch, P., Grasso, C., Gumuskaya, G., Levin, M., and Bongard, J. (2023), Searching in the Dark: Evolving Biobot Swarm Compositions to Efficiently Explore Obstructed Environments, Proceedings of ALIFE 2023: Ghost in the Machine, article 70, doi:10.1162/isal_a_00683
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Rouleau, N., and Levin, M. (2023), Multiple ways to implement and infer sentience: Commentary on Segundo-Ortiz & Calvo on Plant Sentience, Animal Sentience, 8(33): 30
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Masuelli, S., Real, S., McMillen, P., Oudin, M., Levin, M., and Roqué, M. (2023), The Yin and Yang of Breast Cancer: Ion Channels as Determinants of Left-Right Functional Differences, International Journal of Molecular Sciences, 24(13): 11121
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Witkowski, O., Doctor, T., Solomonova, E., Duane, B., and Levin, M. (2023), Towards an Ethics of Autopoietic Technology: Stress, Care, and Intelligence, Biosystems, 231: 104964
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Cervera, J., Levin, M., and Mafé, S. (2023), Bioelectricidad en agregados multicelulares de células no excitables: modelos biofísicos, Revista Española de Física, 37(2): 24-29
Ciaunica, A., Shmeleva, E. V., and Levin, M. (2023), The Brain is not Mental! Coupling Neuronal and Immune Cellular Processing in Human Organisms, Frontiers in Integrative Neuroscience, 17: 1057622
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Fields, C., and Levin, M. (2023), Regulative development as a model for origin of life and artificial life studies, Biosystems, 229: 104927
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Watson, R., and Levin, M. (2023), The collective intelligence of evolution and development, Collective Intelligence, 2(2), doi:10.1177/26339137231168355
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Levin, M. (2023), Bioelectric networks: the cognitive glue enabling evolutionary scaling from physiology to mind, Animal Cognition, doi:10.1007/s10071-023-01780-3
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Fields, C., Fabrocini, F., Friston, K., Glazebrook, J. F., Hazan, H., Levin, M., and Marcianò, A. (2023), Control flow in active inference systems Part II: Tensor networks as general models of control flow, IEEE Transactions on Molecular, Biological, and Multi-Scale Communications, doi:10.1109/TMBMC.2023.3272158
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Fields, C., Fabrocini, F., Friston, K., Glazebrook, J. F., Hazan, H., Levin, M., and Marcianò, A. (2023), Control flow in active inference systems Part I: Classical and quantum formulations of active inference, IEEE Transactions on Molecular, Biological, and Multi-Scale Communications, doi:10.1109/TMBMC.2023.3272150
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Levin, M. (2023), Darwin’s agential materials: evolutionary implications of multiscale competency in developmental biology, Cellular and Molecular Life Sciences, 80: 142
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Pio-Lopez, L., and Levin, M. (2023), Morphoceuticals: Perspectives for discovery of drugs targeting anatomical control mechanisms in regenerative medicine, cancer and aging, Drug Discovery Today, 28(6): 103585
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Mathews, J., Chang, J., Devlin, L., and Levin, M. (2023), Cellular Signaling Pathways as Plastic, Proto-cognitive Systems: Implications for Biomedicine, Patterns, 4: 100737
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Blackiston, D., Kriegman, S., Bongard, J., and Levin, M. (2023), Biological Robots: Perspectives on an Emerging Interdisciplinary Field, Soft Robotics, 10(4): 694-686
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Manicka, S., Johnson, K., Levin, M., and Murrugarra, D. (2023), The nonlinearity of regulation in biological networks, npj Systems Biology and Applications, 9(1): 10
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Bongard, J., and Levin, M. (2023), There’s Plenty of Room Right Here: Biological Systems as Evolved, Overloaded, Multi-Scale Machines, Biomimetics, 8(1): 110
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Davies, J., and Levin, M. (2023), Synthetic morphology with agential materials, Nature Reviews Bioengineering, 1(1): 46-59
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Shreesha, L., and Levin, M. (2023), Cellular Competency during Development Alters Evolutionary Dynamics in an Artificial Embryogeny Model, Entropy, 25(1): 131
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Cervera, J., Levin, M., and Mafe, S. (2023), Bioelectricity of non-excitable cells and multicellular pattern memories: Biophysical modeling, Physics Reports, 1004: 1-31, doi:10.1016/j.physrep.2022.12.003
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Biswas, S., Clawson, W., and Levin. M. (2023), Learning in Transcriptional Network Models: Computational Discovery of Pathway-level Memory and Effective Interventions, International Journal of Molecular Sciences, 24(1): 285
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Cervera, J., Manzanares, J. A., Levin, M., and Mafe, S. (2023), Transplantation of fragments from different planaria: a bioelectrical model for head regeneration, Journal of Theoretical Biology, 558: 111356
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2022
< Back to YearsHazan, H., and Levin, M. (2022), Exploring the Behavior of Bioelectric Circuits Using Evolution Heuristic Search, Bioelectricity, 4(4): 207-227
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Dechiraju, H., Selberg, J., Jia, M., Pansodtee, P., Li, H., Hsieh, H-C., Hernandez, C., Asefifeyzabadi, N., Nguyen, T., Baniya, P., Marquez, G., Rasmussen-Ivey, C., Bradley, C., Teodorescu, M., Gomez, M., Levin, M., and Rolandi, M. (2022), On-chip on-demand delivery of K+ for in vitro bioelectronics, AIP Advances, 12(12): 125205
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Pio-Lopez, L., Kuchling, F., Tung, A., Pezzulo, G., and Levin, M. (2022), Active Inference, Morphogenesis, and Computational Psychiatry, Frontiers in Computational Neuroscience, 16: 988977
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Fields, C., Friston, K., Glazebrook, J. F., Levin, M., and Marcianò, A. (2022), The Free Energy Principle induces neuromorphic development, Neuromorphic Computing and Engineering, 2: 042002
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McMillen, P., and Levin, M. (2022), Information Theory as an experimental tool for integrating disparate biophysical signaling modules, International Journal of Molecular Sciences, 23(17): 9580
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Cavuoti, L., Sacco, F., Randazzo, E., & Levin, M. (2022), Adversarial Takeover of Neural Cellular Automata, Proceedings of the 2022 Conference on Artificial Life (ALIFE 2022), p. 256-263
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Smiley, P., and Levin, M. (2022), Competition for Finite Resources as Coordination Mechanism for Morphogenesis: an evolutionary algorithm study of digital embryogeny, BioSystems, 221: 104672
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Pai, V. P., Cooper, B. G., and Levin, M. (2022), Screening Biophysical Sensors and Neurite Outgrowth Actuators in Human Induced-Pluripotent-Stem-Cell-Derived Neurons, Cells, 11(16): 2470
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Levin, M. (2022), Generalizing frameworks for sentience beyond natural species, Animal Sentience, 7(32): 15
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Pai, V. P., and Levin, M. (2022), HCN2 Channel-induced Rescue of Brain, Eye, Heart, and Gut Teratogenesis Caused by Nicotine, Ethanol, and Aberrant Notch Signaling, Wound Repair and Regeneration, 30(6): 681-706
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Doctor, T., Witkowski, O., Solomonova, E., Duane, B., and Levin, M. (2022), Biology, Buddhism, and AI: Care as the Driver of Intelligence, Entropy, 24(5): e24050710
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Fields, C., and Levin, M. (2022), Competency in Navigating Arbitrary Spaces as an Invariant for Analyzing Cognition in Diverse Embodiments, Entropy, 24(6): 819
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Fields, C., Glazebrook, J. F., and Levin, M. (2022), Neurons as hierarchies of quantum reference frames, Biosystems, 219: 104714
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Fields, C., Friston, K., Glazebrook, J. F., and Levin, M. (2022), A free energy principle for generic quantum systems, Progress in Biophysics and Molecular Biology, 173: 36-59
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Kuchling, F., Fields, C., and Levin, M. (2022) Metacognition as a Consequence of Competing Evolutionary Time Scales, Entropy, 24(5): 601
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Watson, R. A., Levin, M., and Buckley, C. L. (2022) Design for an Individual: Connectionist approaches to the evolutionary transitions in individuality,
Frontiers in Ecology and Evolution, 10: 823588
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Levin, M. (2022), Technological Approach to Mind Everywhere: an experimentally-grounded framework for understanding diverse bodies and minds, Frontiers in Systems Neuroscience, 16: 768201
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Kudithipudi, D., Aguilar-Simon, M., Babb, J., Bazhenov, M., Blackiston, D., Bongard, J., Brna, A. P., Raja, S. C., Cheney, N., Clune, J., Daram, A., Fusi, S., Helfer, P., Kay, L., Ketz, N., Kira, Z., Kolouri, S., Krichmar, J. L., Kriegman, S., Levin, M., Madireddy, S., Manicka, S., Marjaninejad, A., McNaughton, B., Miikkulainen, R., Navratilova, Z., Pandit, T., Parker, A., Pilly, P. K., Risi, S., Sejnowski, T. J., Soltoggio, A., Soures, N., Tolias, A. S., Urbina-Meléndez, D., Valero-Cuevas, F. J., van de Ven, G. M., Vogelstein, J. T., Wang, F., Weiss, R., Yanguas-Gil, A., Zou, X., and Siegelmann, H. (2022), Biological underpinnings for lifelong learning machines, Nature Machine Intelligence, 4(3): 196-210
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Sperry, M. M., Murugan, N. J., and Levin, M. (2022), Studying Protista WBR and Repair Using Physarum polycephalum, in S. Blanchoud and B. Galliot (eds.), Whole-Body Regeneration: Methods in Molecular Biology, 2450: 51-67
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Mathews, J., Kuchling, F., Baez-Nieto, D., Diberardinis, M., Pan, J. Q., and Levin, M. (2022), Ion Channel Drugs Suppress Cancer Phenotype in NG108-15 and U87 Cells: Toward Novel Electroceuticals for Glioblastoma, Cancers 14(6): 1499
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Grodstein, J., and Levin, M. (2022), A Computational Approach to Explaining Bioelectrically-induced Persistent, Stochastic Changes of Axial Polarity in Planarian Regeneration, Bioelectricity, 4(1): 18-30
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Adelfio, M., Bonzanni, M., Levin, M., and Kaplan, D. L. (2022), Impact of Membrane Voltage on Formation and Stability of Human Renal Tubules in Vitro, ACS Biomaterials Science & Engineering, 8(3): 1239-1246
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Masuelli, S., Sebastian, R., Campoy, E., Branham, M. T., Marzese, D. M., Matthew, S., DeBlas, G., Rodolfo, A., Levin, M., and Roque, M. (2022), When left does not seem right: epigenetic and bioelectric differences between left- and right-sided breast cancer, Molecular Medicine, 28(1): 15
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Manicka, S., and Levin, M. (2022), Minimal developmental computation: a causal network
approach to understand morphogenetic pattern formation,
Entropy, 24: 107
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Payne, S. L., Ram, P., Srinivasan, D. H., Le, T. T., Levin, M., and Oudin, M. J. (2022), Potassium channel-driven bioelectric signalling regulates metastasis in triple-negative breast cancer, EBioMedicine, 75: 103767
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2021
< Back to Years
Yuste, R., and Levin, M. (2021), New Clues about the Origins of Biological Intelligence, Scientific American, December 2021
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Kriegman, S., Blackiston, D., Levin, M., and Bongard, J. (2021), Kinematic self-replication in reconfigurable organisms,
Proceedings of the National Academy of Science, 118(49): e2112672118
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Abramson, C., and Levin, M. (2021), Behaviorist Approaches to Investigating Memory
and Learning: A Primer for Synthetic Biology and Bioengineering, Communicative & Integrative Biology, 14(1): 230-247
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Minh-Thai, T. N., Samarasinghe, S., and Levin, M. (2021), A Comprehensive Conceptual and Computational Dynamics Framework for Autonomous Regeneration Systems,
Artificial Life, 27(2): 80-104
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Riol, A., Cervera, J., Levin, M., and Mafe, S. (2021), Cell Systems Bioelectricity: How Different Intercellular Gap Junctions Could Regionalize a Multicellular Aggregate,
Cancers, 13(21): 5300
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Grodstein, J., and Levin, M. (2021), Stability and robustness properties of bioelectric networks: A computational approach,
Biophysics Review, 2: 031305
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Guidetti, G., Levy, G., Matzeu, G., Finkelstein, J. M., Levin, M., and Omenetto, F. G. (2021), Unmixing octopus camouflage by multispectral mapping of Octopus bimaculoides' chromatic elements, Nanophotonics, 10(9): 2441-2450
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McMillen, P., Oudin, M. J, Levin, M., and Payne, S. L. (2021), Beyond Neurons:
Long Distance Communication in Development and Cancer, Frontiers in Cell and Developmental Biology, 9: 739024
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Levin, M. (2021), Bioelectrical approaches to cancer as a
problem of the scaling of the cellular self,
Progress in Biophysics and Molecular Biology, 165: 102-113
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Kriegman, S., Nasab, A-M., Blackiston, D., Steele, H., Levin, M., Kramer-Bottiglio, R., and Bongard, J. (2021), Scale invariant robot behavior with fractals, Robotics: Science and Systems (RSS 2021), doi:10.15607/RSS.2021.XVII.059
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Cervera, J., Levin, M., and Mafe, S. (2021), Morphology changes induced by intercellular gap junction blocking: a reaction-diffusion mechanism, BioSystems, 209: 104511
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Fields, C., and Levin, M. (2021), Metabolic limits on classical information
processing by biological cells, BioSystems, 209: 104513
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Davidian, D., and Levin, M. (2021), Inducing Vertebrate Limb Regeneration: A Review of Past Advances and Future Outlook, Cold Spring Harbor Perspectives in Biology,
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Fields, C., Glazebrook, J. F., and Levin, M. (2021), Minimal physicalism as a scale-free substrate for cognition and consciousness, Neuroscience of Consciousness, 2021(2): niab013
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Niklasson, E., Mordvintsev, A., Randazzo, E., and Levin, M. (2021), Self-organising Textures: Neural Cellular Automata Model of Pattern Formation, Distill, 6(2), doi:10.23915/distill.00027.003
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Randazzo, E., Mordvintsev, A., Niklasson, E., and Levin, M. (2021),
Adversarial Reprogramming of Neural Cellular Automata: a robustness investigation, Distill, 6(5), doi:10.23915/distill.00027.004
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Ebrahimkhani, M., and Levin, M. (2021), Synthetic living machines: A new
window on life, iScience, 24(5): 102505
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Blackiston, D., Lederer, E., Kriegman, S., Garnier, S., Bongard, J., and Levin, M. (2021),
A cellular platform for the development of synthetic living machines, Science Robotics, 6(52): eabf1571
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Levin, M. (2021), Unlimited plasticity of embodied, cognitive subjects: a new playground for the UAL framework, Biology and Philosophy, 36(2): 17
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Rouleau, N., Cairns, D. M., Rusk, W., Levin, M., and Kaplan, D. (2021), Learning and synaptic plasticity in 3D bioengineered neural tissues Neuroscience Letters, 750: 135799
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Levin, M. (2021), Bioelectric Signaling: Reprogrammable Circuits
Underlying Embryogenesis, Regeneration, and Cancer, Cell, 184(8): 1971-1989
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Levin, M., Keijzer, F., Lyon, P., and Arend, D. (2021), Uncovering cognitive similarities and differences, conservation and innovation, Philosophical Transactions of the Royal Society B, 376(1821): 20200458 [cover]
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Shah, D., Yang, B., Kriegman, S., Levin, M., Bongard, J., and Kramer-Bottiglio, R. (2021),
Shape changing robots: bioinspiration, simulation, and physical realization,
Advanced Materials, 33(19): 2170150
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Srivastava, P., Kane, A., Harrison, C., and Levin, M. (2021), A Meta-Analysis of Bioelectric Data in Cancer, Embryogenesis, and Regeneration, Bioelectricity, 3(1): 42-67
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Pezzulo, G., Lapalme, J., Durant, F., and Levin, M. (2021), Bistability of Somatic Pattern Memories: Stochastic Outcomes in Bioelectric Circuits Underlying Regeneration,
Philosophical Proceedings of the Royal Society B, 376(1821): 20190765
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Biswas, S., Manicka, S., Hoel, E., and Levin, M. (2021), Gene Regulatory Networks
Exhibit Several Kinds of Memory: Quantification of Memory in Biological and Random Transcriptional Networks, iScience, 24(3): 102131
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Nanos, V., and Levin, M. (2021), Rewiring Endogenous Bioelectric Circuits in the Xenopus laevis Embryo Model, in M. R. Ebrahimkhani and J. Hislop (Eds.), Programmed Morphogenesis: Methods in Molecular Biology, 2258: 93-103
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Pentagna, N., Pinheiro da Costa, T., Soares Dos Santos, F., Martins de Almeida,
F., Martinez, A. M. B., Abreu, J. G., Levin, M., and Carneiro, K. (2021),
Epigenetic control of myeloid cells behavior by Histone Deacetylase Activity (HDAC)
during tissue and organ regeneration in Xenopus laevis,
Developmental and Comparative Immunology, 114: 103840
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2020
< Back to YearsRandazzo, E., Mordvintsev, A., Niklasson, E., Levin, M., and Greydanus, S. (2020), Self-classifying MNIST Digits Achieving Distributed Coordination with Neural Cellular Automata, Distill, 5(8), doi:10.23915/distill.00027.002
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Mordvintsev, A., Randazzo, E., Niklasson, E., and Levin, M. (2020), Growing Neural Cellular Automata: Differentiable Model of Morphogenesis, Distill, 5(2), doi:10.23915/distill.00027.002
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Cervera, J., Ramirez, P., Levin, M., and Mafe, S. (2020), Community effects allow bioelectrical reprogramming of cell membrane potentials in multicellular aggregates: Model simulations, Physical Review E, 102(5): 052412
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Fields, C., and Levin, M. (2020), How Do Living Systems Create Meaning?, Philosophies, 5(4): 36
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Sousounis, K., Erdogan, B., Levin, M., and Whited, J. L. (2020), Precise control of
ion channel and gap junction expression is required for patterning of the regenerating axolotl limb, International Journal of Developmental Biology, 64(10-11-12): 485-494
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Fields, C., and Levin, M. (2020), Why isn't sex optional? Stem-cell competition,
loss of regenerative capacity, and cancer in metazoan evolution, Communicative & Integrative Biology, 13(1): 170-183
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Levin, M., and Dennett, D. C. (2020), How to understand cells, tissues and organisms as agents with agendas, Aeon Essays
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Fields, C., and Levin, M. (2020), Does evolution have a target morphology?, Organisms. Journal of Biological Sciences, 4(1): 57-76
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Erndt-Marino, J., Yeisley, D. J., Chen, H., Levin, M., Kaplan, D. L., and Hahn, M. S. (2020), Interferon-Gamma Stimulated Murine Macrophages In Vitro: Impact of Ionic Composition and Osmolarity and Therapeutic Implications, Bioelectricity, 2(1): 48-58
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Jia, M., Dechiruji, H., Selberg J., Pansodtee P., Mathews, J., Wu, C., Levin, M., Teodorescu, M., and Rolandi, M. (2020),
Bioelectronic Control of Chloride Ions and Concentration with Ag/AgCl Contacts,
APL Materials, 8(9): 091106
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Kuchling, F., Friston, K., Georgiev, G., and Levin, M. (2020), Integrating Variational Approaches to Pattern Formation into a Deeper Physics: Reply to comments on "Morphogenesis as Bayesian Inference: A Variational Approach to Pattern Formation and Manipulation in Complex Biological Systems", Physics of Life Reviews, 33: 125-128
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Leronni, A., Bardella, L., Dorfmann, L., Pietak, A., and Levin, M. (2020), On the coupling of mechanics with bioelectricity and its role in morphogenesis, Journal of the Royal Society Interface, 17(167): 20200177
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Levin, M., and Rajnicek, A. M. (2020), Richard Borgens, 1946-2019, Bioelectricity, 2(2): 205
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Hoel, E., and Levin, M. (2020), Emergence of Informative Higher Scales in Biological Systems: a computational toolkit for optimal prediction and control, Communicative & Integrative Biology, 13(1): 108-118
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Rouleau, N., Bonzanni, M., Erndt-Marino, J., Sievert, K., Ramirez, C., Rusk, W., Levin, M., and Kaplan, D. (2020), A 3D tissue model of traumatic brain injury with excitotoxicity that is inhibited by chronic exposure to gabapentinoids, Biomolecules, 10(8): 1196
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Levin, M., Bongard, J., and Lunshof, J. E. (2020), Applications and ethics of computer-designed organisms, Nature Reviews Molecular Cell Biology, 21(11): 655-656
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Williams, K., Bischof, J., Lee, F., Miller, K., LaPalme, J., Wolfe, B., and Levin, M. (2020), Regulation of axial and head patterning during planarian regeneration by a commensal bacterium, Mechanisms of Development, 163: 103614 [cover]
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Fields, C., and Levin, M. (2020), Scale-Free Biology: Integrating Evolutionary and Developmental Thinking, BioEssays, 42(8): 1900228 [cover]
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Pai, V., Cervera, J., Mafe, S., Willocq, V., Lederer, E., and Levin, M. (2020), HCN2 Channel-induced Rescue of Brain
Teratogenesis via local and long-range bioelectric repair, Frontiers in Cellular Neuroscience, 14: 136
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Cervera, J., Levin, M., and Mafe, S. (2020), Bioelectrical Coupling of Single-Cell States in Multicellular Systems, Journal of Physical Chemistry Letters, 11(9): 3234-3241
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Kuchling, F., Friston, K., Georgiev, G., and Levin, M. (2020), Morphogenesis as
Bayesian Inference: a Variational Approach to Pattern Formation and Control in Complex Biological Systems, Physics of Life Reviews, 33: 88-108
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Jajoo, A., Donlon, C., Shnayder, S., Levin, M., and McVey, M. (2020), Sertraline induces DNA damage and cellular toxicity in Drosophila that can be ameliorated by antioxidants, Scientific Reports, 10: 4512
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Levin, M. (2020), Revisiting Burr and Northrop's 'The Electro-Dynamic Theory of Life', Biological Theory, 15: rr83-90
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Sousounis, K., Bryant, D. M., Fernandez, J. M., Eddy, S. S., Tsai, S. L., Gundberg, G. C., Han, J., Courtemanche, K., Levin, M., and Whited, J. L. (2020), Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration, eLIFE, 9: e51217
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Kriegman, S., Nasab, A. M., Shah, D., Steele, H., Branin, G., Levin, M., Bongard, J. and Kramer-Bottiglio, R. (2020),
Scalable sim-to-real transfer of soft robot designs,
Proceedings of the 3rd IEEE International Conference on Soft Robotics (RoboSoft 2020), p. 359-366
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Fields, C., and Levin, M. (2020), Does regeneration recapitulate phylogeny? Communicative & Integrative Biology, 13(1): 27-38
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Herrera-Rincon, C., Paré, J-F., Martyniuk, C. J., Jannetty, S. K., Harrison C., Fischer, A., Dinis, A., Keshari, V., Novak, R., and Levin, M. (2020),
An in vivo brain-bacteria interface: the developing brain as a key regulator of innate immunity, npj Regenerative Medicine, 5:2
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Davison, A., McDowell, G. S., Holden, J. M., Johnson, H. F., Wade, C. M., Chiba, S., Jackson, D. J., Levin, M., and Blaxter, M. L. (2020),
Formin, an opinion, Development, 147: dev187427
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Bonzanni, M., Rouleau, N., Levin, M., and Kaplan, D. L. (2020), Optogenetically induced cellular habituation in non-neuronal cells, PLOS One, 15(1): e0227230
PDF
Kriegman, S., Blackiston, D., Levin, M., and Bongard, J. (2020), A scalable pipeline for designing reconfigurable organisms, Proceedings of the National Academy of Sciences of the United States, 432(2): 605-620
PDF
Kamaldinov, T., Erndt-Marino, J., Levin, M., Kaplan, D. L., and Hahn, M. S. (2020), Assessment of Enrichment of Human Mesenchymal Stem Cells Based on Plasma and Mitochondrial Membrane Potentials, Bioelectricity,
PDF
Healy, D., Faber, C., Lapalme, J., and Levin, M. (2020), Post-SSRI Sexual Dysfunction:
a bioelectric mechanism?, Bioelectricity,
PDF
Levin, M. (2020), The Biophysics of Regenerative Repair Suggests New Perspectives on Biological Causation, BioEssays, 42(2): 1900146
PDF
Cervera, J., Meseguer, S., Levin, M., and Mafe, S. (2020), Bioelectrical model of head-tail patterning
based on cell ion channels and intercellular gap junctions, Bioelectrochemistry, 132: 107410
PDF
Fields, C., Bischof, J., and Levin, M. (2020), Morphological Coordination:
A Common Ancestral Function Unifying Neural and Non-Neural Signaling,
Physiology, 35: 16-30
PDF
Bonzanni, M., Payne, S. L., Adelfio, M., Kaplan, D. L., Levin, M., and Oudin, M. J. (2020),
Defined extracellular ionic solutions to study and manipulate the cellular resting membrane potential, Biology Open, 9(1): bio048553
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2019
< Back to YearsLevin, M., Selberg, J., and Rolandi, M. (2019), Endogenous Bioelectrics in Development, Cancer, and Regeneration: Drugs and Bioelectronic Devices as Electroceuticals for Regenerative Medicine, iScience, 22: 519-533
PDF
Manicka, S., and Levin, M. (2019), Modeling somatic computation with non-neural bioelectric networks, Scientific Reports, 9: 18612
PDF
Finkelstein J., McLaughlin K., and Levin M. (2019), Interdisciplinary Approach
Needed to Crack Morphogenesis,
PDF
Levin, M. (2019), The Computational Boundary of a 'Self': Developmental Bioelectricity Drives Multicellularity and Scale-Free Cognition, Frontiers in Psychology, 10: 2688
PDF
Emmons-Bell, M., Durant, F., Tung, A., Pietak, A., Miller, K., Kane, A., Martyniuk, C. J.,
Davidian, D., Morokuma, J., and Levin, M. (2019),
Regenerative Adaptation To Electrochemical Perturbation In Planaria: A Molecular Analysis
Of Physiological Plasticity, iScience, 22: 147-165
PDF
Atsuta, Y., Tomizwa, R. R., Levin, M., and Tabin, C. J. (2019), L-type voltage-gated Ca2+
channel CaV1.2 regulates chondrogenesis during limb development, Proceedings of the
National Academy of Sciences of the United States, 116(43): 21592-21601
PDF
Grasman, J., Williams, M., Razis, C., Bonzanni, M., Golding, A., Cairns, D. M., Levin, M., and Kaplan, D. L. (2019), Hyperosmolar potassium inhibits myofibroblast conversion and reduces scar tissue formation, ACS Biomaterials Science & Engineering, 5(10): 5327-5336
PDF
Levin, S., and Levin, M. (2019), Managing Ideas, People, and Projects:
Organizational Tools and Strategies for Researchers, iScience, 20: 278-291
PDF
Payne, S. L., Levin, M., and Oudin, M. J. (2019), Bioelectric control of metastasis in solid tumors, Bioelectricity, 1(3): 114-130
PDF
Fields, C., and Levin, M. (2019), Somatic Multicellularity as a Satisficing
Solution to the Prediction-Error Minimization Problem,
Communicative & Integrative Biology, 12(1): 119-132
PDF
Punjiya, M., Nehad, H. R., Mathews, J., Levin, M., and Sonkusale, S. (2019), A flow through device for simultaneous dielectrophoretic cell trapping and AC electroporation, Scientific Reports, 9: 11988
PDF
Levin, M., and Martinez-Arias, A. (2019), Reverse-engineering growth and form in Heidelberg, Development, 146(14): dev177261
PDF
Kriegman, S., Walker, S., Shah, D. S., Levin, M., Kramer-Bottiglio, R., and Bongard, J. (2019), Automated Shapeshifting for Function Recovery in Damaged Robots, Proceedings of Robotics: Science and Systems XV: 28
PDF
Bonzanni, M., Rouleau, N., Levin, M., and Kaplan, D. (2019),
On the generalization of habituation: how discrete biological systems
respond to repetitive stimuli, BioEssays, 41(7): 1900028
PDF
Beane, W. S., Adams, D. S., Morokuma, J., and Levin, M. (2019), Live Imaging of Intracellular pH
in Planarians Using the Ratiometric Fluorescent Dye SNARF-5F-AM,
Biology Methods and Protocols, 4(1): bpz005
PDF
Manicka, S., and Levin, M. (2019), The Cognitive Lens: a primer on conceptual tools for analysing
information processing in developmental and regenerative morphogenesis, Philosophical Transactions
of the Royal Society B, 374(1774): 20180369
PDF
Pietak, A., Bischof, J., LaPalme, J., Morokuma, J., and Levin, M. (2019), Neural control of body-plan axis in regenerating planaria,
PLOS Computational Biology, 15(4): e1006904
PDF
Bizzari, M., Brash, D., Briscoe, J., Grieneisen, V., Stern, C. D., and Levin, M. (2019), A Call for a Better Understanding of Causation in Cell Biology, Nature Reviews Molecular Cell Biology, 20(5): 261-262
PDF
Sundelacruz, S., Moody, A. T., Levin, M., and Kaplan, D. (2019), Membrane potential depolarization
alters calcium flux and phosphate signaling during osteogenic differentiation of human mesenchymal stem cells,
Bioelectricity, 1(1): 56-66
PDF
Hammelman, J., Siegelmann, H., Manicka, S., and Levin, M. (2019), Toward modeling regeneration via adaptable echo state networks, in A. Adamatzky, S. Akl, and G. Sirakoulis (Eds.), From parallel to emergent computing, Chapter 6, pages 117-133, CRC Press: Boca Raton, FL
Berard, A., Levin, M., Sadler, T., and Healy, D. (2019),
Selective Serotonin Reuptake Inhibitor Use During Pregnancy and Major Malformations:
The Importance of Serotonin for Embryonic Development and the Effect of Serotonin Inhibition
on the Occurrence of Malformations, Bioelectricity, 1(1): 18-29
PDF
Levin, M., Pietak, A., and Bischof, J. (2019), Planarian Regeneration as a Model of Anatomical
Homeostasis: Recent Progress in Biophysical and Computational Approaches, Seminars in Cell and Developmental Biology, 87: 125-144
PDF
Durant, F., Bischof, J., Fields, C., Morokuma, J., LaPalme, J., Hoi, A., and Levin, M. (2019), The role of early bioelectric signals in the regeneration of planarian anterior/posterior polarity, Biophysical Journal, 116(5): 948-961
PDF
Churchill, C. D. M., Winter, P., Tuszynski, J. A., and Levin, M. (2019), EDEn - Electroceutical Design Environment: Ion Channel Tissue Expression Database with Small Molecule Modulators, iScience,11: 42-56
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2018
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Minh-Thai, T. N., Aryal, J., Samarasinghe, S., and Levin, M. (2018), A Computational Framework for Autonomous Self-repair Systems, in Mitrovic, T., Xue, B., and Li, X. (Eds.), AI 2018: Advances in Artificial Intelligence. Lecture Notes in Computer Science, 11320: 153-159, Springer: Cham
PDF
Link
Lee, F. J., Williams, K. B., Levin, M., and Wolfe, B. E. (2018), The bacterial metabolite indole inhibits regeneration of the planarian flatworm Dugesia japonica, iScience, 10: 135-148
PDF
Herrera-Rincon, C., Golding, A. S., Moran, K. M., Harrison, C., Martyniuk, C. J., Guay, J. A., Zaltsman, J.,
Carabello, H., Kaplan, D. L., and Levin, M. (2018), Brief Local Application of Progesterone via a Wearable
Bioreactor Induces Long-Term Regenerative Response in Adult Xenopus Hindlimb, Cell Reports, 25(6): 1593-1609
PDF
Kamm, R. D., Bashir, R., Arora, N., Dar, R. D., Gilette, M. U., Griffith, L. G., Kemp, M. L., Kinlaw, K., Levin, M., Martin,
A. C., McDevitt, T. C., Nerem, R. M., Powers, M. J., Saif, T. A., Sharpe, J., Takayama, S., Takeuchi, S., Weiss, R.,
Ye, K., Yevick, H. G., and Zaman, M. H. (2018), Perspective: the promise of multi-cellular engineered living systems,
APL Bioengineering, 2(4): 040901
PDF
Cairns, D. M., Giordano, J. E., Conte, S., Levin, M., and Kaplan, D. L. (2018),
Ivermectin promotes peripheral nerve regeneration during wound healing,
ACS Omega, 3(10): 12392-12402
PDF
Hart, M. R., Anderson, D. J., Porter, C. C., Neff, T., Levin, M., and Horwitz, M. S. (2018),
Activating PAX gene family paralogs to complement PAX5 leukemia driver mutations, PLoS Genetics, 14(9): 1007642
PDF
Busse, S. M., McMillen, P. T., and Levin, M. (2018), Cross-limb Communication During Xenopus Hind-limb Regenerative Response: Non-Local Bioelectric Injury Signals, Development, 145(19): dev164210
PDF
Moore, D. G., Walker, S. I., and Levin, M. (2018), Pattern Regeneration in Coupled Networks, in T. Ikegami, N. Virgo, O. Witkowski, M. Oka, R. Suzuki and H. Iizuka (Eds.), ALIFE 2018: The 2018 Conference on Artificial Life. MIT Press: Tokyo,
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Ferreira, G. B. S., Scheutz, M., and Levin, M. (2018), Modeling Cell Migration in a Simulated Bioelectrical Signaling Network for Anatomical Regeneration, in T. Ikegami, N. Virgo, O. Witkowski, M. Oka, R. Suzuki and H. Iizuka (Eds.), ALIFE 2018: The 2018 Conference on Artificial Life.
MIT Press: Tokyo,
PDF
Brodsky, M., and Levin, M. (2018), From Physics to Pattern: Uncovering Pattern Formation in Tissue Electrophysiology, in T. Ikegami, N. Virgo, O. Witkowski, M. Oka, R. Suzuki and H. Iizuka (Eds.), ALIFE 2018: The 2018 Conference on Artificial Life.
MIT Press: Tokyo,
PDF
Moore, D. G., Valentini, G., Walker, S. I., and Levin, M. (2018), Inform: Efficient Information-Theoretic Analysis of Collective Behaviors, Frontiers in Robotics and AI,
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Pezzulo, G., and Levin, M. (2018), Embodying Markov blankets. Comment on 'Answering Schrödinger's question: A free-energy formulation' by Maxwell James Désormeau Ramstead et al., Physics of Life Reviews, 24: 32-36
PDF
Pietak, A., and Levin, M. (2018), Bioelectrical control of positional information in
development and regeneration: a review of conceptual and computational advances,
Progress in Biophysics and Molecular Biology, 137: 52-68
PDF
Mathews, J., and Levin, M. (2018), The Body Electric 2.0: Recent Advances in Developmental
Bioelectricity for Regenerative and Synthetic Bioengineering,
Current Opinion in Biotechnology, 52: 134-144
PDF
Monsoro-Burq, A. H., and Levin, M. (2018), Avian models and the study of invariant asymmetry:
how the chicken and the egg taught us to tell right from left, International Journal of
Developmental Biology, 62(1-3): 63-77
PDF
Fields, C., and Levin, M. (2018), Are planaria individuals? What regenerative
biology is telling us about the nature of multicellularity, Evolutionary Biology,
PDF
Pai, V. P., Pietak, A., Willocq, V., Ye, B., Shi, N-Q., and Levin, M. (2018),
HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns,
Nature Communications, 9(1): 998
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Sullivan, K. G., and Levin, M. (2018), Inverse Drug Screening of Bioelectric Signaling and Neurotransmitter Roles: Illustrated Using a Xenopus Tail Regeneration Assay, Cold Spring Harbor Protocols, 2018(3): 154-163
PDF
Levin, M., and Martyniuk, C. J. (2018), The bioelectric code: An ancient computational medium
for dynamic control of growth and form, BioSystems, 164: 76-93
PDF
Cairns, D. M., Boorgu, D. S. S. K., Levin, M., and Kaplan, D. L. (2018),
Niclosamide rescues microcephaly in a humanized in vivo model of
Zika infection using human induced neural stem cells, Biology Open, 7(1): bio031807
PDF
Vallverdu, J., Castro, O., Mayne, R., Talanov, M., Levin, M., Baluška, F., Gunji, Y., Dussutour, A., Zenil, H., and Adamatzky, A. (2018), Slime mould: the fundamental mechanisms of biological cognition, BioSystems, 165: 57-70
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Moore, D. G., Valentini, G., Walker, S. I., and Levin, M. (2018), Inform: a toolkit for information-theoretic analysis of complex systems, Proceedings of the 2017 IEEE Symposium Series on Computational Intelligence (SSCI), p. 3258-3265
PDF
Ferreira, G. B. S., Scheutz, M., and Levin, M. (2018), Introducing Simulated Stem Cells into a Bio-Inspired Cell-Cell Communication Mechanism for Structure Regeneration, Proceedings of the 2017 IEEE Symposium Series on Computational Intelligence (SSCI), p. 2778-2785
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2017
< Back to YearsTuszynski, J., Tilli, T. M., and Levin, M. (2017), Ion channel and neurotransmitter
modulators as electroceutical approaches to the control of cancer,
Current Pharmaceutical Design, 23(32): 4827-4841
PDF
Pitcairn, E., Harris, H., Epiney, J., Pai, V. P., Lemire, J. M., Ye, B., Shi, N-Q., Levin, M., and McLaughlin, K. A. (2017),
Coordinating heart morphogenesis: A novel role for Hyperpolarization-activated cyclic nucleotidegated
(HCN) channels during cardiogenesis in Xenopus laevis, Communicative & Integrative Biology,
10(3): e1309488 [cover]
PDF
McLaughlin, K. A., and Levin, M. (2017), Bioelectric Signaling in Regeneration:
Mechanisms of Ionic Controls of Growth and Form, Developmental Biology, 433(2): 177-189
PDF
Pai, V. P., Willocq, V., Pitcairn, E. J., Lemire, J. M., Paré, J-F., Shi, N-Q., McLaughlin, K. A., and Levin, M. (2017),
HCN4 Ion Channel Function is Required for Early Events that Regulate Anatomical Left-Right Patterning in
a Nodal- and Lefty Asymmetric gene Expression-Independent Manner, Biology Open, 6(10): 1445-1457
PDF
Moore, D., Walker, S. I., and Levin, M. (2017), Cancer as a Disorder of Patterning Information: computational and biophysical perspectives on the cancer problem, Convergent Science Physical Oncology,
PDF
Adams, D. S., Tseng, A-S., and Levin, M. (2017), Using optogenetics in vivo to stimulate regeneration, in K. Appasani (Ed.), Optogenetics: From Neuronal Function to Mapping and Disease Biology. Cambridge University Press: Cambridge, UK, p. 66-76
Ferreira, G. B., Scheutz, M., and Levin, M. (2017), Investigating the Effects of Noise on a Cell-to-Cell Communication Mechanism for Structure Regeneration, in
C. Knibbe, D. Parsons, D. Misevic, J. Rouzaud-Cornaba, N. Bredèche, S. Hassas, O. Simonin, and H. Soula. (Eds.), Proceedings of the 14th European Conference on Artificial Life (ECAL 2017), Lyon, France, p. 170-177
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Dungan, J., Mathews, J., Levin, M., and Koomson, V. (2017), Microfluidic Platform to Study Intercellular Connectivity Through on-Chip Electrical Impedance Measurement, IEEE 60th International Midwest Symposium on Circuits and Systems, Boston, MA, p.56-69
PDF
Durant, F., Morokuma, J., Fields, C., Williams, K., Adams, D. S., and Levin, M. (2017),
Long-Term, Stochastic Editing of Regenerative Anatomy via Targeting Endogenous
Bioelectric Gradients, Biophysical Journal, 112(10): 2231-2243 [cover]
PDF
Levin, M., Morokuma, J., and Finkelstein, J. (2017), Space travel has effects on
planarian regeneration that cannot be explained by a null hypothesis, Regeneration, 4(4): 156-158
PDF
Mathews, J., and Levin, M. (2017), Gap Junctional Signaling in Pattern Regulation:
physiological network connectivity instructs growth and form, Developmental Neurobiology, 77(5): 643-673
PDF
Levin, M., Pezzulo, G., and Finkelstein, J. M. (2017), Endogenous Bioelectric
Signaling Networks: Exploiting Voltage Gradients for Control of Growth and Form,
Annual Review of Biomedical Engineering, 19: 353-387
PDF
Thurber, A. E., Nelson, M., Frost, C. L., Levin, M., Brackenbury, W. J., and Kaplan, D. L. (2017),
IK channel activation increases tumor growth and induces differential behavioral
responses in two breast epithelial cell lines, Oncotarget, 8(26): 42382-42397
PDF
Blackiston, D., Vien, K., and Levin, M. (2017), Serotonergic stimulation
induces nerve growth and promotes visual learning via posterior eye grafts in
a vertebrate model of induced sensory plasticity, npj Regenerative Medicine, 2: 8
PDF
Lobo, D., Lobikin, M., and Levin, M. (2017), Discovering novel phenotypes with automatically
inferred dynamic models: partial melanocyte conversion in Xenopus,
Scientific Reports, 7: 41339
PDF
Blackiston, D. J., and Levin, M. (2017), Reversals of bodies, brains, and behavior:
quantitative analysis of laterality and its disturbance in model species,
in L. J. Rogers and G. Vallortigara (Eds.), Lateralized Brain Functions: Methods in Human and Non-human Species,
"Neuromethods", W. Walz (Ed.), 122: 667-694
PDF
Garcia-Quismondo, M., Levin, M., and Lobo, D. (2017), Modeling regenerative processes with
Membrane Computing, Information Sciences, 381: 229-249
PDF
Lobo, D., and Levin, M. (2017), Computing a worm: reverse-engineering planarian regeneration, in Adamatzky, A. (Ed), Advances in Unconventional Computing. Emergence, Complexity and Computation, vol 23, Springer: Cham, pp. 637-654
De, Abhishek, Chakravarthy, V. S., and Levin, M. (2017), A Computational Model of Planarian Regeneration, International Journal of Parallel, Emergent, and Distributed Systems, 32(4): 331-347
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2016
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Levin, M., Klar, A. J. S., and Ramsdell, A. (2016), Introduction to provocative questions in Left-Right asymmetry, Philosophical Transactions of the Royal Society B, 371(1710): 20150399
PDF
Pezzulo, G., and Levin, M. (2016), Top-down models in biology: explanation and control of complex living systems above the molecular level, Journal of the Royal Society Interface, 13(124): 20160555
PDF
Herrera-Rincon, C., Guay, J., and Levin, M. (2016), Bioelectrical coordination
of cell activity toward anatomical target states: an engineering perspective on regeneration,
Chapter 4 in D. Gardiner (Ed.), Regenerative Engineering and Developmental Biology: Principles and Applications,
CRC Press: Boca Raton, FL, p. 55-112
Link
Ferreira, G., Smiley, M., Scheutz, M., and Levin, M. (2016), Dynamic structure discovery and repair for 3D cell assemblages, Proceedings of the Fifteenth International Conference on the Synthesis and Simulation of Living Systems (ALIFEXV), p. 352-359
PDF
Serlin, Z., Rife, J., and Levin, M. (2016), A Level Set Approach to Simulating Xenopus laevis Tail Regeneration, Proceedings of the Fifteenth International Conference on the Synthesis and Simulation of Living Systems (ALIFEXV), p. 528-535
PDF
Pietak, A., and Levin, M. (2016), Exploring Instructive Physiological Signaling with the Bioelectric Tissue Simulation Engine , Frontiers in
Bioengineering and Biotechnology, 4: 55
PDF
Baluška, F., and Levin, M. (2016), On Having No Head: Cognition throughout Biological Systems, Frontiers in Psychology, 7: 902
PDF
Pai, V. P., Martyniuk, C. J., Echeverri, K., Sundelacruz, S., Kaplan, D. L., and Levin, M. (2016), Genome-wide analysis reveals conserved transcriptional responses downstream of resting potential change in Xenopus embryos, axolotl regeneration, and human mesenchymal cell differentiation, Regeneration, 3(1): 3-25
PDF
Sullivan, K. G., Emmons-Bell, M., and Levin, M. (2016), Physiological Inputs Regulate Species-Specific Anatomy During Embryogenesis And Regeneration,
Communicative & Integrative Biology, 9(4): e1192733 [cover]
PDF
Lobo, D., Morokuma, J., and Levin, M. (2016), Computational discovery and in vivo validation of hnf4 as a regulatory gene in planarian re-generation,
Bioinformatics, 32(17): 2681-2685
PDF
Edelstein, L., Fuxe, K., Levin, M., Popescu, B., and Smythies, J. (2016), Telocytes in their context with other intercellular communication agents, Seminars in Cell and Developmental Biology, 55: 9-13
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Davison, A., McDowell, G. S., Holden, J. M., Johnson, H. F., Koutsovoulos, G. D., Liu, M. M., Hulpiau, P., Van Roy, F., Wade, C. W., Banerjee, R., Yang, F., Chiba, S., Davey, J. W., Jackson, D. J., Levin, M., and Blaxter, M. L., (2016), Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog, Current Biology, 26(5): 654-660 [cover]
PDF
Sullivan, K. G., and Levin, M. (2016), Neurotransmitter signaling pathways required
for normal development in Xenopus laevis embryos: a pharmacological survey screen,
Journal of Anatomy, 229(4): 483-502 [cover]
PDF
Adams, D. S., Uzel, S. G. M., Akagi, J., Wlodkowic, D., Andreeva, V., Yelick, P. C., Devitt-Lee, A., Paré, J-F., and Levin, M. (2016), Bioelectric signaling via potassium channels: a mechanism for craniofacial dysmorphogenesis in KCNJ2-associated Andersen-Tawil Syndrome, Journal of Physiology, 594(12): 3245-3270 [cover]
PDF
Li, C., Levin, M., and Kaplan, D. (2016), Bioelectric modulation of macrophage polarization, Scientific Reports, 6: 21044
PDF
Dimonte, A., Adamatzky, A., Erokhin, V., and Levin, M. (2016), On chirality of slime mould, BioSystems, 140: 23-27
PDF
Whiting, J. G. H., Jones, J., Bull, L., Levin, M., and Adamatzky, A. (2016), Towards a
physarum learning chip, Scientific Reports, 6: 19948
PDF
Hammelman, J., Lobo, D., and Levin, M. (2016), Artificial neural networks as models
of robustness in development and regeneration: stability of memory during morphological
remodeling, in S. Shanmuganathan and S. Samarasinghe (Eds.), Artificial Neural Network (ANN) Modeling. Studies in Computational Intelligence, vol. 628, pp. 45-65
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2015
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Emmons-Bell, M., Durant, F., Hammelman, J., Bessonov, N., Volpert, V., Morokuma, J., Pinet, K., Adams, D. S., Pietak, A., Lobo, D., and Levin, M. (2015), Gap junctional blockade stochastically induces different species-specific head anatomies in genetically wild-type Girardia dorotocephala flatworms, International Journal of Molecular Sciences, 16(11): 27865-27896 [cover]
PDF
Pang, J., Özkucur, N., Ren, M., Kaplan, D. L., Levin, M., and Miller, E. L. (2015),
Automatic neuron segmentation and neural network analysis method for phase contrast microscopy images, Biomedical Optics Express, 6(11): 4395-4416
PDF
Lobikin, M., Lobo, D., Blackiston, D. J., Martyniuk, C. J., Tkachenko, E., and Levin, M. (2015), Serotonergic regulation of melanocyte conversion: A bioelectrically regulated network for stochastic all-or-none hyperpigmentation, Science Signaling, 8(397): ra99
PDF
Law, R., and Levin, M. (2015), Bioelectric memory: modeling resting potential
bistability in amphibian embryos and mammalian cells, Theoretical Biology and
Medical Modelling, 12(1): 22
PDF
Bessonov, N., Levin, M., Morozova, N., Reinberg, N., Tosenberger, A., and Volpert, V. (2015), Target morphology and cell memory: a model of regenerative pattern formation, Neural Regeneration Research, 10(12): 1901-1905 [cover]
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Pai, V. P., Lemire, J. M., Chen, Y., Lin, G., and Levin, M. (2015), Local and long-range endogenous resting potential gradients antagonistically regulate apoptosis and proliferation in the embryonic CNS, International Journal of Developmental Biology, 59(7-9): 327-340
PDF
Lobo, D., and Levin, M. (2015), Inferring regulatory networks from experimental morphological phenotypes:
a computational method reverse-engineers planarian regeneration, PLoS Computational Biology, 11(6): e1004295
PDF
Tosenberger, A., Bessonov, N., Levin, M., Reinberg, N., Volpert, V., and Morozova, N. (2015), A conceptual model of morphogenesis and regeneration, Acta Biotheoretica, 63(3): 283-294
PDF
Levin, M. (2015), Gap junctions: versatile mediators of long-range developmental signals, The Node
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Levin, M. (2015), Nerves read the electrical typography of their microenvironment in making growth decisions, The Node
Full text
Friston, K., Levin, M., Sengupta, B., and Pezzulo, G. (2015), Knowing one's place: a free energy approach to pattern regulation, Journal of the Royal Society Interface, 12(105): 20141383
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Pai, V., Lemire, J. M., Paré, J-F., Lin, G., Chen, Y., and Levin, M. (2015), Endogenous gradients
of resting potential instructively pattern embryonic neural tissue via Notch signaling
and regulation of proliferation, Journal of Neuroscience, 35(10): 4366-4385
PDF
Özkucur, N., Quinn, K. P., Pang, J. C., Du, C., Georgakoudi, I., Miller, E., Levin, M., and Kaplan, D. L. (2015), Membrane potential depolarization causes alterations in neuron arrangement and connectivity in cocultures, Brain and Behavior, 5(1): 24-38
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Bessonov, N., Levin, M., Morozova, N., Reinberg, N., Tosenberger, A., and Volpert, V. (2015),
On a model of pattern recognition based on cell memory, PLoS One, 10(2): e0118091
PDF
Blackiston, D., Anderson, G. M., Rahman, N., Bieck, C., and Levin, M. (2015), A novel method for inducing nerve growth via modulation of host resting potential,
Neurotherapeutics, 12(1): 170-184
PDF
Chernet, B. T., Fields, C., and Levin, M. (2015), Long-range gap junctional signaling controls oncogene-mediated tumorigenesis in Xenopus laevis embryos, Frontiers in Physiology, 5: 519
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2014
< Back to YearsLevin, M. (2014), Molecular bioelectricity: how endogenous voltage potentials control cell behavior
and instruct pattern regulation in vivo, Molecular Biology of the Cell, 25(24): 3835-3850
PDF
Jewhurst, K., Levin, M., and McLaughlin, K. A. (2014), Optogenetic Control of Apoptosis in Targeted Tissues of Xenopus laevis Embryos, Journal of Cell Death, 7: 25-31
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Adams, D. S., Lemire, J. M., Kramer, R. H., and Levin, M. (2014), Optogenetics in developmental biology: using light to control ion flux-dependent signals in Xenopus embryos, International Journal of Developmental Biology, 58(10-12): 851-861
PDF
Vandenberg, L. N., Blackiston, D. J., Rea, A. C., Dore, T. M., and Levin, M. (2014),
Left-right patterning in Xenopus conjoined twin embryos requires serotonin signaling
and gap junctions, International Journal of Developmental Biology, 58(10-12): 799-809
PDF
Zhu, F., Skommer, J., Huang, Y., Akagi, J., Adams, D. S., Levin, M., Hall, C. J., Crosier, P. S., and Wlodkowic, D. (2014), Fishing on chips: up-and-coming technological advances in analysis of zebrafish and Xenopus embryos, Cytometry A, 85A(11): 921-932
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Lobo, D., Feldman, E. B., Shah, M., Malone, T. J., and Levin,
M. (2014), Limbform: a functional ontology-based
database of limb regeneration experiments,
Bioinformatics, 30(24): 3598-3600
PDF
Lan, J. Y., Williams, C., Levin, M., and Black, L. D. III (2014), Depolarization of Cellular Resting Membrane Potential Promotes Neonatal Cardiomyocyte Proliferation In Vitro, Cellular and Molecular Bioengineering, 7(3): 432-445
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Mustard, J., and Levin, M. (2014), Bioelectrical mechanisms for programming
growth and form: taming physiological networks for soft body robotics, Soft Robotics, 1(3): 169-191
PDF
Lobo, D., Feldman, E. B., Shah, M., Malone, T., and Levin, M. (2014),
A bioinformatics expert system linking functional data to
anatomical outcomes in limb regeneration, Regeneration,
1(2): 37-56
PDF
Budnikova, M., Habig, J. W., Cornia, N., Levin, M., Lobo, D., and Andersen, T. (2014), Design of a flexible component gathering algorithm forconverting cell-based models to graph representations for use inevolutionary search, BMC Bioinformatics, 15(1): 178
PDF
Hernandez-Diaz, S., and Levin, M. (2014), Alteration of bioelectrically-controlled processes in the embryo: a teratogenic mechanism for anticonvulsants, Reproductive Toxicology, 47: 111-114
PDF
Pai, V., and Levin, M. (2014), Bioelectric controls of stem cell function,
Chapter 5 in F. Calegari and C. Waskow (Eds.), Stem Cells: From Basic Research to Therapy, Volume 1, CRC Press: Boca Raton, FL, pp. 106-148
Amazon book
Levin, M. (2014), Endogenous bioelectrical networks store non-genetic patterning information during development and regeneration, Journal of Physiology, 592(11): 2295-2305
PDF
Lobo, D., Solano, M., Bubenik, G. A., and Levin, M. (2014), A linear-encoding model
explains the variability of the target morphology in regeneration,
Journal of the Royal Society Interface, 11(92): 20130918
PDF
Lobikin, M., and Levin, M. (2014), Endogenous bioelectric cues as morphogenetic signals in vivo, Chapter 15 in D. Fels, M. Cifra, and F. Scholkmann (Eds), Fields of the Cell, Research Signpost: Kerala, India, pp. 283-302
PDF
Lange, C., Prenninger, S., Knuckles, P., Taylor, V., Levin, M., and Calegari, F. (2014), V-ATPase maintains neural stem cells in the developing mouse cortex, in S. Nakamuri (Ed.), Handbook of H+ ATPases, Pan Stanford Pte. Ltd: Singapore, pp. 413-430
PDF
2013
< Back to YearsVandenberg, L. N., Lemire, J. M, and Levin, M. (2013), It's Never too Early
to get it Right: A Conserved Role for the Cytoskeleton in Left-Right Asymmetry,
Communicative & Integrative Biology, 6(6): e27155
PDF
Levin, M. (2013), Remembrance of Brains Past, The Node
Full text
Rea, A. C., Vandenberg, L. N., Ball, R. E., Snouffer, A. A., Hudson, A. G., Zhu, Y., McLain, D. E., Johnston, L. L., Lauderdale J. D., Levin, M., and Dore, T. M. (2013), Light-activated serotonin for exploring its action in biological systems, Chemistry & Biology, 20(12): 1536-1546
PDF
Sundelacruz, S., Li, C., Choi, Y. J., Levin, M., and Kaplan, D. L. (2013) Bioelectric modulation of wound healing in a 3D in vitro model of tissue-engineered bone, Biomaterials, 34(28): 6695-705
PDF
Sundelacruz, S., Levin, M., and Kaplan, D. L. (2013), Depolarization Alters
Phenotype, Maintains Plasticity of Predifferentiated Mesenchymal Stem Cells,
Tissue Engineering Part A, 19(17-18): 1889-1908
PDF
Levin, M. (2013), Reprogramming cells and tissue patterning via bioelectrical pathways: molecular mechanisms and biomedical opportunities, Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 5(6): 657-676
PDF
Shomrat, T., and Levin, M. (2013), An automated training paradigm reveals long-term memory in planaria and its persistence through head regeneration, Journal of Experimental Biology, 216(20): 3799-3810
PDF |
Overview
Levin, M. (2013), Bioelectrical signaling has rich history, Physics Today, 66(9): 11
PDF
Vandenberg, L. N., and Levin, M. (2013), A unified model for left-right asymmetry? Comparison and synthesis of molecular models of laterality, Developmental Biology, 379(1): 1-15 [cover]
PDF
Vandenberg, L. N., Morrie, R. D., Seebohm, G., Lemire, J. M., and Levin, M. (2013), Rab GTPases are required for early orientation of the left-right axis in Xenopus, Mechanisms of Development, 130(4-5): 254-271 [cover]
PDF
Blackiston, D. J., and Levin, M. (2013), Ectopic eyes outside the head in Xenopus tadpoles provide sensory data for light-mediated learning, Journal of Experimental
Biology, 216(6): 1031-1040
PDF
Koustubhan, P., Kaplan, D., and Levin, M. (2013), Humane anesthesia and pain management in amphibian limb surgery of Rana pipiens, Cold Spring Harbor Protocols, 2013(2): 149-155 [cover]
PDF
Tseng, A-S., and Levin, M. (2013), Cracking the bioelectric code: probing endogenous ionic controls of pattern formation, Communicative & Integrative Biology,
6(1): e22595 [cover]
PDF
Vandenberg, L. N., Lemire, J. M., and Levin, M. (2013), Serotonin has early, cilia-independent roles in Xenopus left-right patterning, Disease Models and Mechanisms, 6(1): 261-268 [cover]
PDF
Beane, W. S., Morokuma, J., Lemire, J. M., and Levin, M. (2013), Bioelectric signaling regulates head and organ size during planarian regeneration, Development, 140(2): 313-322
PDF
2012
< Back to YearsVandenberg, L. N., Stevenson, C., and Levin, M. (2012), Low frequency vibrations induce malformations in two aquatic species in a frequency-, waveform-, and direction-specific
manner, PLoS One, 7(12): e51473
PDF
Pai, V. P., Vandenberg, L. N., Blackiston, D. J., and Levin, M. (2012), Neurally derived tissues in Xenopus laevis embryos exhibit a consistent bioelectrical left-right asymmetry, Stem Cells International, 2012: 353491
PDF
Lobikin, M., Wang, G., Xu, J.-S., Hsieh, Y.-W., Chuang, C.-F., Lemire, J. M., and Levin, M. (2012), Early, nonciliary role for microtubule proteins in left-right patterning is conserved across kingdoms, Proceedings of the National Academy of Sciences of the United States, 109(31): 12586-12591
PDF
Tseng, A.-S., and Levin, M. (2012), Transducing bioelectrical signals into
epigenetic pathways during tadpole tail regeneration, Anatomical Record, 295(10): 1541-1551
PDF
Vandenberg, L. N., Adams, D. S., and Levin, M. (2012), Normalized shape and location of perturbed craniofacial structures in the Xenopus tadpole reveal an innate ability to achieve correct morphology, Developmental Dynamics, 241(5): 863-878 [cover]
PDF
Beane, W. S., Tseng, A.-S., Morokuma, J. M., Lemire, J. M., and Levin, M. (2012), Inhibition of planar cell polarity extends neural growth during regeneration, homeostasis, and development, Stem Cells and Development, 21(12):
2085-2094 [cover]
PDF
Chernet, B. T., and Levin, M. (2012), A versatile protocol for mRNA electroporation of Xenopus laevis embryos, Cold Spring Harbor Protocols, 2012(4): 447-452
PDF
Adams, D. S., and Levin, M. (2012), Measuring resting membrane potential using the fluorescent voltage reporters
PDF
Pai, V., Aw, S., Shomrat, T., Lemire, J. M., and Levin, M. (2012), Transmembrane
voltage potential controls embryonic eye patterning in Xenopus laevis,
Development, 139(2): 313-323
PDF
Vandenberg, L. N., and Levin, M. (2012), Polarity proteins are required for left-right axis orientation and twin-twin instruction,Genesis,
PDF
Levin, M., and Stevenson, C. (2012), Regulation of Cell Behavior and Tissue Patterning by Bioelectrical Signals: challenges and opportunities for biomedical engineering, Annual Reviews in Biomedical Engineering, 14: 295-323
PDF
2011
< Back to Years
Beane, W. S., Morokuma, J., Adams, D. S., and Levin, M. (2011),A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration, Chemistry & Biology,
PDF
Lange, C., Prenninger, S., Knuckles, P., Taylor, V., Levin, M., and Calegari, F. (2011), The H(+) vacuolar ATPase maintains neural stem cells in the developing mouse cortex, Stem Cells and Development, 20(5): 843-850
PDF
Carneiro, K., Donnet, C., Rejtar, T., Karger, B. L., Díaz, E., Kortagere, S., Lemire, J. M., and Levin, M. (2011), Histone deacetylase activity is necessary for left-right patterning during vertebrate development, BMC Developmental Biology, 11: 29
PubMed |
PDF
Vandenberg, L. N., Pennarola, B. W., and Levin, M. (2011), Low frequency vibrations disrupt left-right patterning in the Xenopus embryo, PLoS One, 6(8): e23306
PDF
Mondia, J. P., Adams, D. S., Orendorff, R. D., Levin, M., and Omenetto, F. (2011), Patterned femtosecond-laser ablation of Xenopus laevis melanocytes for studies of cell migration, wound repair, and developmental processes, Biomedical Optics Express, 2(8): 2383-2391
PDF
Mondia, J. P., Levin, M., Omenetto, F. G., Orendorff, R. D., Branch, M. R., and Adams, D. S. (2011), Long-distance signals are required for morphogenesis of the regenerating
Xenopus tadpole tail as shown by femtosecond-laser ablation, PLoS One, 6(9): e24953
PDF
Tseng, A-S., Carneiro, K., Lemire, J. M., and Levin, M. (2011),HDAC activity is required during Xenopus tail regeneration, PLoS One, 6(10): e26382
PDF
Levin, M. (2011), Endogenous Bioelectric Signals as Morphogenetic Controls of Development, Regeneration, and Neoplasm, in C. Pullar (Ed.), The Physiology of Bioelectricity in Development, Tissue Regeneration, and Cancer, CRC Press: Boca Raton, FL, pp. 39-89
Available here
Levin, M. (2011), The wisdom of the body: future techniques and approaches to morphogenetic fields in regenerative medicine, developmental biology, and cancer,
Regenerative Medicine, 6(6): 667-673
PDF
2010
< Back to YearsBlackiston, D., Shomrat, T., Nicolas, C. L., Granata, C., and Levin, M. (2010), A second-generation device for automated
training and quantitative behavior analyses of molecularly-tractable model organisms, PLoS One, 5(12): e14370
PDF
Oviedo, N. J., Morokuma, J., Walentek, P., Kema, I. P., Gu, M. B., Ahn, J. M., Hwang, J. S., Gojobori, T., and Levin, M. (2010), Long-range Neural and Gap Junction Protein-mediated Cues Control Polarity During Planarian Regeneration, Developmental Biology, 339(1): 188-199 [cover]
PDF
Aw, S., Koster, J., Pearson, W., Nicols, C., Shi, N. Q., Carneiro, K., and Levin, M. (2010), The ATP-sensitive K+-channel (KATP) controls early left-right patterning in Xenopus and chick embryos, Developmental Biology, 346(1): 39-53
PDF
Hechavarria, D., Dewilde, A., Braunhut, S., Levin, M., and Kaplan, D. K. (2010), BioDome regenerative sleeve for biochemical and biophysical stimulation of tissue regeneration, Medical Engineering and Physics, 32(9): 1065-1073
PDF
Blackiston, D., Vandenberg, L. N., and Levin, M. (2010), High-throughput Xenopus laevis immunohistochemistry using agarose sections, Cold Spring Harbor Protocols,
2010(12): 1364-1371
PDF
Vandenberg, L. N., and Levin, M. (2010), Far from solved: a perspective on what we know about early mechanisms of left-right asymmetry, Developmental Dynamics, 239(12): 3131-3146 [cover]
PDF
2009
< Back to YearsAw, S., and Levin, M. (2009), Molecular mechanisms establishing consistent left-right asymmetry during vertebrate embryogenesis, in I. E. C Sommer and R. S. Kahn (Eds.), Language Lateralization and Psychosis, Cambridge University Press: Cambridge, UK, 3-18
PDF
Aw, S., and Levin, M. (2009), Is left-right asymmetry a form of planar cell polarity? Development, 136(3): 355-366
PDF
Zhang, Y., and Levin, M. (2009), Particle tracking model
of electrophoretic morphogen movement reveals stochastic
dynamics of embryonic gradient, Developmental Dynamics,
238(8): 1923-1935
PDF
Zhang, Y., and Levin, M. (2009), Left-right asymmetry in
the chick embryo requires core planar cell polarity protein
Vangl2, Genesis, 47(11): 719-728
PDF
Levin, M. (2009), Bioelectric mechanisms in regeneration: Unique aspects and future perspectives, Seminars in Cell and Developmental Biology, 20(5): 543-556
PDF
Sundelacruz, S., Levin, M., and Kaplan, D. L. (2009), Role of membrane potential in the regulation of cell proliferation and differentiation, Stem Cell Reviews,
5(3): 231-246
PDF
2008
< Back to YearsMorokuma, J., Blackiston, D., and Levin, M. (2008), KCNQ1 and KCNE1 K+ channel components are involved in early left-right patterning in Xenopus embryos, Cellular Physiology and Biochemistry, 21(5-6): 357-372
PDF
Oviedo, N. J., Pearson, B. J., Levin, M., and Alvarado, A. S. (2008), Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling, Disease Models and Mechanisms, 1(2-3): 131-143
PDF
Morokuma, J., Blackiston, D., Adams, D. S., Seebohm, G., Trimmer, B., and Levin, M. (2008), Modulation of potassium channel confers a hyperproliferative invasive phenotype on embryonic stem cells, Proceedings of the National Academy of Sciences of the United States, 105(43): 16608-16613
PDF
Sundelacruz, S., Levin, M., and Kaplan, D. L. (2008), Membrane potential controls adipogenic and osteogenic differentiation of mesenchymal stem cells, PLoS One, 3(11): e3737
PDF
Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M. (2008), Live imaging of planarian membrane potential using DiBAC4(3), Cold Spring Harbor Protocols, 3(10): pdb.prot5055
PDF
Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M. (2008), Gene knockdown in planarians using RNA interference, Cold Spring Harbor Protocols, 3(10): pdb.prot5054
PDF
Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M. (2008), Establishing and maintaining a colony of planarians, Cold Spring Harbor Protocols, 3(10): pdb.prot5053
PDF
Oviedo, N., and Levin, M. (2008), The planarian regeneration model as a context for the study of drug effects and mechanisms, in R. B. Raffa & S. M. Rawls (Eds.), Planaria: A Model for Drug Action and Abuse, RG Landes Co.: Austin, pp. 95-104
Nicolas, C.L., Abramson, C.I., and Levin, M. (2008), Analysis of behavior in the planarian model, in R. B. Raffa & S. M. Rawls (Eds.), Planaria: A Model for Drug Action and Abuse, RG Landes Co.: Austin, pp. 83-94
Aw, S., and Levin, M. (2008), What's Left in Asymmetry? Developmental Dynamics, 237(12): 3453-3464
PDF
Oviedo, N., Nicolas, C. L., Adams, D. S., and Levin, M. (2008), Planarians: a versatile and powerful model system for molecular studies of regeneration, adult stem cell regulation, aging, and behavior, Cold Spring Harbor Protocols, 3(10): pdb.em0101
PDF
Oviedo, N., Nicolas, C. L., Adams, D. S., and Levin, M. (2008),Planarians: a versatile and powerful model system for molecular
studies of regeneration, adult stem cell regulation, aging, and behavior, in Emerging Model Organisms: A Laboratory Manual, Volume 1, Cold Spring Harbor Press: Cold Spring Harbor, NY
PDF | Book
Tseng, A-S., and Levin, M. (2008), Tail regeneration in Xenopus laevis as a model for understanding tissue repair,
Journal of Dental Research, 87(9): 806-816
PDF
2007
< Back to YearsTseng, A-S., Adams, D. S., Qiu, D., Koustubhan, P., and Levin, M. (2007), Apoptosis is required during early stages of tail regeneration in Xenopus laevis, Developmental Biology, 301(1): 62-69
PDF
Oviedo, N. J., and Levin, M. (2007), smedxin-11 is a Planarian Stem Cell Gap Junction Gene Required for Regeneration and Homeostasis, Development, 134(17): 3121-3131
PDF
Aw, S., Adams, D. S., Qiu, D., and Levin, M. (2007), H,K-ATPase protein localization and Kir4.1 function reveal concordance of three axes during early determination of left-right
asymmetry, Mechanisms of Development, 125(3-4): 353-372
PDF
Koustubhan, P., Sorocco, D., and Levin, M. (2007), Establishing and maintaining a Xenopus laevis colony for research laboratories, in P. M. Conn (Ed.), Source Book of Models for Biomedical Research, Humana Press: Totowa NJ, pp. 139-160
PDF
Levin, M., and Palmer, R. (2007), Left-right patterning from the inside out: widespread evidence for intracellular control, BioEssays, 29(3): 271-287
PDF
Levin, M. (2007), Large-Scale Biophysics: Ion Flows and Regeneration, Trends in Cell Biology, 17(6): 261-270 [cover]
PDF
Oviedo, N., and Levin, M. (2007), Gap junctions provide new links in left-right patterning, Cell, 129(4): 645-647
PDF
2006
< Back to YearsHibino, T., Ishii, Y., Levin, M., and Nishino, A. (2006), Ion flow regulates left-right asymmetry in sea urchin development, Development Genes and Evolution, 216(5): 265-76
PDF
Shimeld, S. M., and Levin, M. (2006), Evidence for the regulation of left-right asymmetry in Ciona intestinalis by ion flux, Developmental Dynamics, 235(6): 1543-1553
PDF
Adams, D. S., Robinson, K. R., Fukumoto, T., Yuan, S., Albertson, R. C., Yelick, P., Kuo, L., McSweeney, M., and Levin, M. (2006), Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates, Development, 133(9): 1657-1671
PDF
Hicks, C., Sorocco, D., and Levin, M. (2006), Automated Analysis of Behavior: A Computer-Controlled System for Drug Screening and the Investigation of Learning, Journal of Neurobiology, 66(9): 977-990
PDF
Esser, A. T., Smith, K. C., Weaver, J. C., and Levin, M. (2006), Mathematical Model of Morphogen Electrophoresis through Gap Junctions, Developmental Dynamics, 235(8): 2144-2159
PDF
Adams, D. S., and Levin, M. (2006), Inverse Drug Screens: a rapid and inexpensive method for implicating molecular targets, Genesis, 44(11): 530-540
PDF
Adams, D., and Levin, M. (2006), Strategies and techniques for investigation of biophysical signals in patterning, in Analysis of Growth Factor signaling in Embryos, M. Whitman and A. K. Sater eds., pp. 177-264, Methods in Signal Transduction Series, CRC Press
Levin, M. (2006), Is the Early Left-Right Axis like a Plant, a Kidney, or a Neuron? The Integration of Physiological Signals in Left-Right Asymmetry, Birth Defects Research (Part C), 78(3): 191-223
PDF
2005
< Back to YearsFukumoto, T., and Levin, M. (2005), Asymmetric expression of Syndecan-2 in early chick embryogenesis, Gene Expression Patterns , 5(4): 525-528
PDF
Fukumoto, T., Kema, I. P., and Levin, M. (2005), Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos, Current Biology, 15(9): 794-803
PDF
Nogi, T., Yuan, Y. E., Sorocco, D., Perez-Tomas, R., and Levin, M. (2005), Eye regeneration assay reveals an invariant functional left-right asymmetry in the early bilaterian, Dugesia japonica, Laterality, 10(3): 193-205
PDF
Qiu, D., Cheng, S. M., Wozniak, L., McSweeney, M., Perrone, E., and Levin, M. (2005), Localization and loss-of-function implicates ciliary proteins in early, cytoplasmic roles in left-right asymmetry, Developmental Dynamics, 234(1): 176-189
PDF
Shin, J-B., Adams, D., Paukert, M., Siba, M., Sidi, S., Levin, M., Gillespie, P. G., and Grunder, S. (2005), Xenopus TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner-ear hair cells, Proceedings of the National Academy of Sciences of the United States, 102(35): 12572-12577
PDF
Gamer, L. W., Nove, J., Levin, M., and Rosen, V. (2005), BMP-3 is a novel inhibitor of both
activin and BMP-4 signaling in Xenopus embryos, Developmental Biology, 285(1): 156-168
PDF
Nogi, T., and Levin, M. (2005), Characterization of innexin gene expression and functional roles of gap-junctional communication in planarian regeneration, Developmental Biology, 287(2): 314-335
PDF
Levin, M. (2005), Left-right asymmetry in embryonic development: a comprehensive review, Mechanisms of Development, 122(1): 3-25 [cover]
PDF
2004
< Back to YearsLevin, M. (2004), A novel immunohistochemical method
for evaluation of antibody specificity and detection of labile
targets in biological tissue, Journal of Biophysical
and Biochemical Methods, 58(1): 85-96
PDF
Levin, M. (2004), The embryonic origins of left-right
asymmetry, Critical Reviews in Oral Biology and
Medicine, 15(4): 197-206
PDF
Adams, D. S., and Levin, M. (2004), Early Patterning of the
Left/Right Axis, in C. D. Stern (Ed.), Gastrulation: from cells to
embryo, Cold Spring Harbor: New York, pp. 403-417
PDF
2003
< Back to YearsBunney, T. D., De Boer, A. H., and Levin, M. (2003),
Fusicoccin signaling reveals 14-3-3 protein function as a novel step
in left-right patterning during amphibian embryogenesis,
Development, 130(20): 4847-4858
PDF
Levin, M. (2003), Bioelectromagnetics in
morphogenesis, Bioelectromagnetics, 24(5): 295-315
PDF
Levin, M. (2003), Motor protein control of ion flux is an early
step in embryonic left-right asymmetry, BioEssays, 25(10): 1002-1010
PDF
2002
< Back to YearsLevin, M., Thorlin, T., Robinson, K., Nogi, T., and Mercola, M. (2002),
Asymmetries in H+/K+-ATPase and cell membrane potentials comprise
a very early step in left-right patterning,
Cell, 111(1): 77-89
PDF
Rutenberg, J., Cheng, S. M., and Levin, M. (2002), Early
embryonic expression of ion channels and pumps in chick and
Xenopus development, Developmental Dynamics, 225(4):
469-484
PDF
Cheng, S. M., Chen, I., and Levin, M. (2002), Katp channel
activity is required for hatching in Xenopus embryos,
Developmental Dynamics, 225(4): 588-591
PDF
Levin, M. (2002), Isolation and community: A review of
the role of gap-junctional communication in embryonic patterning,
Journal of Membrane Biology, 185(3): 177-192
PDF
2001
< Back to YearsMercola, M., and Levin, M. (2001), Left-Right asymmetry
determination in vertebrates, Annual Review of Cell and
Developmental Biology, 17: 779-805
PDF
Levin, M. (2001), Asymmetry of Body and Brain: Embryological
and Twin Studies, in N. Smelser and P. Baltes (Eds.),
International Encyclopedia of the Social and Behavioral Sciences, Elsevier: Oxford, UK, pp. 853-859
PDF
2000
< Back to YearsLevin, M., and Mercola, M. (2000), Expression of
connexin 30 in Xenopus embryos and its involvement in hatching
gland function, Developmental Dynamics, 219(1): 96-101
PDF
1999
< Back to YearsLevin, M. (1999), Matrix-based GA representations in a model of evolving animal communication, in L. Chambers (Ed.), The Practical Handbook of Genetic Algorithms: Complex Coding Systems, Vol. 3, ch.5, pp. 103-117, CRC Press: Boca Raton, FL
Levin, M. (1999), Twinning and embryonic
left-right asymmetry, Laterality, 4(3): 197-208
PDF
Zhu, L., Marvin, M. J., Gardiner, A., Lassar, A. B., Mercola, M., Stern, C. D., and Levin, M. (1999),
Cerberus regulates left-right asymmetry of the embryonic head and heart,
Current Biology, 9(17): 931-938
PDF
Levin, M., and Mercola, M. (1999), Gap Junction-Mediated Transfer of
Left-Right Patterning Signals in the Early Chick Blastoderm is Upstream of
Shh Asymmetry in the Node, Development, 126(21): 4703-4714
PDF
Levin, M. (1999), Left-right asymmetry in animal
embryogenesis, in G. Palyi, C. Zucchi, and L. Caglioti (Eds.),
Advances in Biochirality, ch. 12, pp. 137-152, Elsevier Science LTD: Oxford, UK
PDF
Levin, M. (1999), Endogenous electromagnetic fields and radiations in regeneration, development, and neoplasm, Proceedings of the First World Congress on the Effects of Electricity and Magnetism in the Natural World, Madeira, Portugal
1998
< Back to YearsLevin, M. (1998), The roles of activin and follistatin
signaling in chick gastrulation, International Journal of
Developmental Biology, 42(4): 553-559
PDF |
Figures
Levin, M., and Mercola, M. (1998), Gap junctions
are involved in the early generation of left right asymmetry,
Developmental Biology, 203(1): 90-105
PDF
Levin, M., and Mercola, M. (1998), Evolutionary conservation of
mechanisms upstream of asymmetric nodal expression: Reconciling chick and Xenopus,
Developmental Genetics, 23(3): 185-193
PDF
Levin, M. (1998), Left-Right asymmetry and the chick embryo,
Seminars in Cell & Developmental Biology, 9(1): 67-76
PDF
Levin, M., and Mercola, M. (1998), The compulsion of chirality:
toward an understanding of left-right asymmetry,
Genes & Development, 12(6): 763-769
PDF
1997
< Back to YearsLevin, M., and Ernst, S. G. (1997), Applied DC magnetic fields
cause alterations in the time of cell divisions and developmental abnormalities
in early sea urchin embryos, Bioelectromagnetics, 18(3): 255-263
PDF
Levin, M., Pagan, S., Roberts, D. J., Cooke, J., Kuehn, M. R., and Tabin, C. J. (1997),
Left/Right Patterning Signals and the Independent Regulation of Different
Aspects of Situs in the Chick Embryo, Developmental Biology, 189(1): 57-67
PDF
Levin, M. (1997), Left-right asymmetry in vertebrate embryogenesis,
BioEssays, 19(4): 287-296 [cover]
PDF |
Link
1996
< Back to YearsLevin, M., Roberts, D. J., Holmes, L. B., and Tabin, C. (1996),
Laterality defects in conjoined twins, Nature,
384(6607): 321
PDF
1995
< Back to YearsLevin, M., and Ernst, S. G. (1995), Applied AC and DC Magnetic Fields
Cause Alterations in the Mitotic Cycle of Early Sea Urchin Embryos,
Bioelectromagnetics, 16(4): 231-240
PDF
Levin, M. (1995), Use of Genetic Algorithms to Solve
Biomedical Problems, M.D. Computing, 12(3): 193-198
PDF
Levin, M. (1995), The evolution of understanding: A genetic algorithm model of the evolution of animal communication, BioSystems, 36(3): 167-178
PDF
Levin, M. (1995), Locating putative protein signal
sequences, in L. Chambers (Ed.), The Practical Handbook of Genetic Algorithms:
New Frontiers, Vol. 2, ch. 2, pp. 53-66, CRC Press: Boca
Raton, FL
PDF
1994
< Back to YearsLevin, M. (1994), A Julia set model of field-directed morphogenesis: developmental biology
and artificial life, Computer Applications in the Biosciences, 10(2): 85-103
PDF
Levin, M., (1994), Discontinuous and alternate
q-system fractals, Computers and Graphics, 18(6): 873-884
PDF
1993
< Back to YearsLevin, M. (1993), Current and potential applications of bioelectromagnetics in medicine, Subtle Energies & Energy Medicine Journal, 4(1): 77-87
PDF
Conferences, Abstracts, and Poster Sessions
< Back to Years- Etcheverry, M., Levin, M., Moulin-Frier, C., and Oudeyer, P.-Y. (2023), SBMLtoODEjax: Efficient Simulation and Optimization of Biological Network Models in JAX, NeurIPS 2023 AI for Science Workshop, New Orleans, LA
- Murugan, N., Vigran, H., Miller, K., Pham, Q., Golding, A., Kane, A., Kaplan, D., and Levin, M. (2021), Brief multi-drug treatment via a wearable silk-hydrogel bioreactor induces long-term limb re-patterning and regeneration in adult Xenopus Laevis, The FASEB Journal, 35(S1), doi:10.1096/fasebj.2021.35.s1.03874
- Novak, R., Choe, Y., Dinis, A., Ingram, M., Keshari, V., Nestor, B. A., Super, M., Levin, M., and Ingber, D. E. (2020), Xenopticon: Microfluidic platform for time-resolved analysis of Xenopus embryo development, Proceedings of 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017), 1639-1640
- Blackiston, D., Adams, D., Lemire, J., and Levin, M. (2010), Transmembrane voltage gradient in GlyR-expressing niche cells controls behavior of neural crest derivatives in vivo, Developmental Biology, 344(1): 526
- Oviedo, N. J., Morokuma, J., Walentek, P., Kema, I. P., Gu, M. B., Ahn, J.M., Hwang, J. S., Gojobori, T., and Levin, M. (2010), Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration, Developmental Biology, 344(1): 522
- Tseng, A. S., Beane, W. S., Lemire, J. M., Masi, A., and Levin, M. (2010), NaV-mediated sodium transport is required for vertebrate appendage regeneration, Developmental Biology, 344(1): 519
- Beane W. S., Morokuma J., and Levin M. (2010), H,K-ATPase-mediated ion transport regulates anterior patterning in regenerating planaria, Developmental Biology, 344(1): 522
- Vandenberg, L., and Levin, M. (2010), The Par6 complex is required for both early and late orientation of the left-right axis in Xenopus, Developmental Biology, 344(1): 426-427
- Beane, W. S., Oviedo, N.J., Adams, D. S., and Levin, M. (2009), H,K-ATPase-mediated ion transport regulates anterior patterning in regenerating planaria, Mechanisms of Development, 126(S1): S294-S295
- Morokuma, J., and Levin, M. (2006), Role of KvLQT-1/minK K+ channel in early embryonic patterning, Developmental Biology, 295(1): 451-
- Blum, M., Schweickert, A., Beyer, T., Weber, T., Andre, P., Fischer, A., Viebahn, C., and Levin, M. (2006), A leftward fluid flow precedes nodal induction in Xenopus, Developmental Biology, 295(1): 443
- Adams, D. S., Masi, A., and Levin, M. (2006), Xenopus tadpole tail regeneration requires the activity of the proton pump V- ATPase, and proton pumping is sufficient to partially rescue the loss of function phenotype, Developmental Biology, 295(1): 355-356
- Levin, M., Adams, D. S., Aw, S., Morokuma, J., and Oviedo, N. J. (2006), Bioelectrical controls of morphogenesis, Developmental Biology, 295(1):331-332
- Chen, I., and Levin, M. (2004), The Role of KATP Channels in Development of Left-Right Asymmetry in Xenopus, Journal of Dental Research, 83: A1340
- Nogi, T. and Levin, M. (2003), Electrical Controls of Regeneration in Planaria, Developmental Biology, 259: 586
- Levin, M. (2003), Electric Embryos: Endogenous Ion Fluxes and Voltage Gradients in Left—Right Asymmetry, Developmental Biology, 259: 482
- Adams, D., and Levin, M. (2003), Elements of Left—Right Patterning: Gap Junctions, pH, and Membrane Voltage, Developmental Biology, 259: 482
- Fukumoto, T., and Levin, M. (2003), Serotonin Is a Novel Very Early Signaling Mechanism in Left—Right Asymmetry, Developmental Biology, 259: 490
- Levin, M., and Mercola, M. (1999), Gap junction-mediated transfer of left-right patterning signals, Molecular Biology of the Cell, 39: 1
- Pagan S. M., Levin M., and Tabin C. (1997),From left-right asymmetric gene expression to its morphological manifestations, Journal of Morphology, 232(3): 306
- Levin, M., Gonzalez, J. L., and Ernst, S. G. (1991), DC and AC magnetic field effects on early sea-urchin development, Biological Bulletin, 181: 511-
