Preprints

Pigozzi, F., Goldstein, A., Levin, M. (2024), Associative Conditioning in Gene Regulatory Network Models Increases Integrative Causal Emergence, OSF Preprints, doi:10.31219/osf.io/2bc4n
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Varley, T. F., Pai, V. P., Grasso, C., Lunshof, J., Levin, M., Bongard, J. (2024), Identification of brain-like functional information architectures in embryonic tissue of Xenopus laevis, bioRxiv, doi:10.1101/2024.12.05.627037
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Dehghani, N., Levin, M. (2024), Bio-inspired AI: Integrating Biological Complexity into Artificial Intelligence, arxiv, doi:10.48550/arXiv.2411.15243
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Pietak, A., Levin, M. (2024), Harnessing the analog computing power of regulatory networks with the Regulatory Network Machine, OSF Preprints, doi: 10.31219/osf.io/tb5ys
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Hartl, B., Zhang, Y., Hazan, H., Levin M. (2024), Heuristically Adaptive Diffusion-Model Evolutionary Strategy, arxiv, doi: 10.48550/arXiv.2411.13420
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Lyons, B.F., Levin, M. (2024), Cognitive Glues Are Shared Models of Relative Scarcities: The Economics of Collective Intelligence, OSF Preprints, doi: 10.31219/osf.io/3fdya
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Kofman, K., Levin, M. (2024), Robustness of the Mind-Body Interface: case studies of unconventional information flow in the multiscale living architecture, OSF Preprints, doi: 10.31219/osf.io/fqm7r
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Gumuskaya, G., Davey, N., Srivastava, P.,  Bender, A., Pio-Lopez, L., Hazel, D., Levin, M. (2024), The morphological, behavioral, and transcriptomic life cycle of Anthrobots, OSF Preprints, doi: 10.31219/osf.io/whm5u
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Levin, M., Rouleau, N. (2024), Discussions of machine vs. living intelligence need more clarity, OSF Preprints, doi: 10.31219/osf.io/gz3km
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Tolchinsky, A., Levin, M., Chris Fields, C., Da Costa, L., Murphy, R., Friedman, D., Pincus, D. (2024), Temporal Depth in a Coherent Self and in Depersonalization: Theoretical Model, OSF Preprints, doi: 10.31219/osf.io/gjxhn
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Sediqi, H., Levin, M. (2024), Bioelectric Characterization of Senescing Human Keratinocytes, OSF Preprints, doi: 10.31219/osf.io/py86e
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Sacco, F., Sakthivadivel, D., Levin, M. (2024), Requirements for self organization, Github, doi: 10.5281/zenodo.8416764
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Zhang, Y., Hartl, B., Hazen, H., Levin, M. (2024), Diffusion Models are Evolutionary Algorithms, arxiv, doi: 10.48550/arXiv.2410.02543
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Le, N.H., Watson, R. A., Buckley, C., Levin, M. (2024), Emergent Collective Reproduction via Evolving Neuronal Flocks, arXiv, doi: 10.48550/arXiv.2409.13254
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Kuchling, F., Singh, I., Daga, M., Zec, S., Kunen, A., Levin, M. (2024), Uncertainty Minimization and Pattern Recognition in Volvox Carteri and Volvox Aureus, OSF Preprints, doi: 10.31219/osf.io/kdjtx
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Pai, V. P., Pio-Lopez, L., Sperry, M. M., Erickson, P., Levin, M. (2024), Xenobot Transcriptomics: Gene Expression Changes in wild-type cells forming a synthetic biobot, OSF Preprints, doi: 10.31219/osf.io/n2jre
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Hansali, S., Pio-Lopez, L., LaPalme, J. V, Levin, M. (2024), The Role of Bioelectrical Patterns in Regulative Morphogenesis: An Evolutionary Simulation and Validation in Planarian Regeneration, Preprints, 2024082041 doi: 10.20944/preprints202408.2041.v1
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Levin, M. (2024), The multiscale wisdom of the body: collective intelligence as a tractable interface for next-generation biomedicine, OSF Preprints, doi:10.31219/osf.io/yq9xe
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Sole, R., Conde, N., Pla Mauri, J., Garcia Ojalvo, J., Montserrat, N., Levin, M. (2024), Open Problems in Synthetic Multicellularity, Preprints, doi:10.20944/preprints202407.1896.v1
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Hartl, B., Levin, M., Zöttl, A.(2024),  Neuroevolution of Decentralized Decision-Making in N-Bead Swimmers Leads to Scalable and Robust Collective Locomotion, arxiv, doi:10.48550/arXiv.2407.09438
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Pio-Lopez, L., Levin, M. (2024),  Universal Multilayer Network Embedding Reveals a Causal Link Between GABA Neurotransmitter and Cancer, OSF Preprints, doi:10.31219/osf.io/d78wb
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Blackiston, D., Dromiack, H., Grasso, C., Varley, T. F., Moore, D. G., Srinivasan, K., Sporns, O., Bongard, J., Levin, M., Walker, S.I. (2024),  Revealing non-trivial information structures in aneural biological tissues via functional connectivity, bioRxiv, doi:10.1101/2024.05.09.593467
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Levin, M. (2024), AI: a Bridge toward Diverse Intelligence and Humanity’s Future, PsyArXiv, doi:10.31234/osf.io/ez263
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Hartl, B., Risi, S., and Levin, M. (2024), Evolutionary Implications of Multi-Scale Intelligence, OSF Preprints, doi:10.31219/osf.io/sp9kf
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Shreesha, L., and Levin, M. (2024), Stress Sharing as Cognitive Glue for Collective Intelligences: a computational model of stress as a coordinator for morphogenesis, OSF Preprints, doi:10.31219/osf.io/9y8ku
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Levin, M. (2024), Self-improvising Memories: a perspective on memories as agential, dynamically-reinterpreting cognitive glue, OSF Preprints, doi:10.31219/osf.io/4b2wj
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Tissot, T., Levin, M., Buckley, C., and Watson, R. (2024), An ability to respond begins with inner alignment: How phase synchronisation effects transitions to higher levels of agency, bioRxiv, doi:10.1101/2024.02.16.580248
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Kofman, K., and Levin, M. (2024), Bioelectric Pharmacology of Cancer: A Meta-Analysis of Ion Channel Drugs Affecting the Cancer Phenotype, OSF Preprints, doi:10.31219/osf.io/qkuvf
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Zhang, T., Goldstein, A., and Levin, M. (2023), Classical Sorting Algorithms as a Model of Morphogenesis: self-sorting arrays reveal unexpected competencies in a minimal model of basal intelligence, OSF Preprints, doi:10.31219/osf.io/e5d4u
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Etcheverry, M., Moulin-Frier, C., Oudeyer, P.-Y., and Levin, M. (2023), AI-driven Automated Discovery Tools Reveal Diverse Behavioral Competencies of Biological Networks, OSF Preprints, doi:10.31219/osf.io/s6thq
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Li, H., Yang, H.-Y., Asefifeyzabadi, N., Baniya, P., Medina Lopez, A., Gallegos, A., Zhu, K., Hsieh, H.-C., Nguyen, T., Hernandez, C., Zlobina, K., Recendez, C., Tebyani, M., Carrión, H., Selberg, J., Luo, L., Alhamo, M. A., Soulika, A. M., Levin, M., Norouzi, N., Gomez, M., Zhao, M., Teodorescu, M., Isseroff, R. R., and Rolandi, M. (2023), Programmable delivery of fluoxetine via wearable bioelectronics for wound healing in vivo, bioRxiv, doi:10.1101/2023.10.10.561754
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Sacco, F., Sakthivadivel, D., and Levin, M. (2023), Requirements for self organization: What do you need to have a structure emerge spontaneously?, Github, doi:10.5281/zenodo.8416764
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O’Brien, T., Stremmel, J., Pio-Lopez, L., McMillen, P., Rasmussen-Ivey, C., and Levin, M. (2023), Machine Learning for Hypothesis Generation in Biology and Medicine: Exploring the latent space of neuroscience and developmental bioelectricity, OSF Preprints, doi:10.31219/osf.io/269e5
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Etcheverry, M., Levin, M., Moulin-Frier, C., and Oudeyer, P.-Y. (2023), SBMLtoODEjax: efficient simulation and optimization of ODE SBML models in JAX, arXiv, doi:10.48550/arXiv.2307.08452
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Tung, A., Sperry, M., Clawson, W., Pavuluri, A., Bulatao, S., Yue, M., Flores, R. M., Pai, V. McMillen, P., Kuchling, F., and Levin, M. (2023), Embryos Assist Each Other’s Morphogenesis: calcium and ATP signaling mechanisms in collective resistance to teratogens, OSF Preprints, doi:10.31219/osf.io/ps987
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Pio-Lopez, L., and Levin, M. (2023), Aging as a morphostasis defect: a developmental bioelectricity perspective, OSF Preprints, doi:10.31219/osf.io/wkhx4
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Ciaunica, A., Levin, M., Rosas, F., and Friston, K. (2023), Nested Selves: Self-Organisation and Shared Markov Blankets in Prenatal Development in Humans, PsyArXiv, doi:10.31234/osf.io/g8q5d
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Masuelli, S., Real, S., McMillen, P., Oudin, M., Levin, M., and Roqué, M. (2023), The Yin and Yang of Breast Cancer: Ion Channels as Determinants of Left-Right Functional Differences, Preprints.org, 2023051160, doi:10.20944/preprints202305.1160.v1
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Fields, C., Fabrocini, F., Friston, K., Glazebrook, J. F., Hazan, H., Levin, M. and Marcianò, A. (2023), Control flow in active inference systems, arXiv, doi:10.48550/arXiv.2303.01514
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Levin, M. (2023), Darwin’s Agential Materials: evolutionary implications of multi-scale competency in developmental biology, OSF Preprints, doi:10.31219/osf.io/p23se
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Witkowski, O., Doctor, T., Solomonova, E., Duane, B., and Levin, M. (2023), Towards an Ethics of Autopoietic Technology: Stress, Care, and Intelligence, PsyArXiv, doi:10.31234/osf.io/pjrd2
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Sperry, M. M., Charrez, B., Fotowat, H., Gardner, E., Pilobello, K., Izadifar, Z., Lin, T., Kuelker, A., Kaki, S., Lewandowski, M., Lightbown, S., Martinez, R., Marquez, S., Sesay, A., Shcherbina, K., Takeda, T., Andrijauskaite, K., Cisneros, E., Lopez, R., Cano, I., Maxwell, Z., Veraza, R., Bunegin, L., Percival, T. J., Yracheta, J., Pena, J. J., Wood, D. M., Homas, Z. T., Hinshaw, C. J., Cox-Hinshaw, J., Parry, O. G., Sleeter, J. J., Weitzel, E., Levin, M., Super, M., Novak, R., and Ingber, D. E. (2023), Identification of a pharmaceutical biostasis inducer that slows metabolism in multiple vertebrates that do not hibernate, bioRxiv, doi:10.1101/2023.02.27.530270
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Manicka, S., Pai, V. P, and Levin, M. (2023), Information integration during bioelectric regulation of morphogenesis in the embryonic frog brain, bioRxiv, doi:10.1101/2023.01.08.523164
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Pio-Lopez, L., and Levin, M. (2022), Morphoceuticals: perspectives for discovery of drugs targeting anatomical control mechanisms in regenerative medicine, cancer, and aging, OSF Preprints, doi:10.31219/osf.io/7hxnp
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Bongard, J., and Levin, M. (2022), There’s Plenty of Room Right Here: Biological Systems as Evolved, Overloaded, Multi-scale Machines, arXiv, doi:10.48550/arXiv.2212.10675
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Pio-Lopez, L., Bischof, J., LaPalme, J. V., and Levin, M. (2022), The scaling of goals via homeostasis: an evolutionary simulation, experiment and analysis, arXiv, doi:10.48550/arXiv.2211.08522
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Mathews, J., Chang, J., Devlin, L., and Levin, M. (2022), Cellular Signaling Pathways as Plastic, Proto-cognitive Systems: Implications for Biomedicine, OSF Preprints, doi:10.31219/osf.io/c6n9r
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Grodstein, J., and Levin, M. (2022), Closing the Loop on Morphogenesis: A Mathematical Model of Morphogenesis by Closed-Loop Reaction-Diffusion, arXiv, doi:10.48550/arXiv.2211.01313
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Hazan, H., and Levin, M. (2022), Exploring The Behavior of Bioelectric Circuits using Evolution Heuristic Search, bioRxiv, doi:10.1101/2022.10.23.513361
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Fields, C., and Levin, M. (2022), Regulative development as a model for origin of life and artificial life studies, PsyArXiv, doi:10.31234/osf.io/rdt7f
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Ciaunica, A., and Levin, M. (2022), The Brain is not Mental! Coupling Neuronal and Immune Cellular Processing in Human Organisms, PsyArXiv, doi:10.31234/osf.io/fgcy5
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Gumuskaya, G., Srivastava, P., Cooper, B. G., Lesser, H., Semegran, B., Garnier, S., and Levin, M. (2022), Motile Living Biobots Self-Construct from Adult Human Somatic Progenitor Seed Cells, bioRxiv, doi:10.1101/2022.08.04.502707
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Shreesha, L., and Levin, M. (2022), Competency of the Developmental Layer Alters Evolutionary Dynamics in an Artificial Embryogeny Model of Morphogenesis, arXiv, doi:10.48550/arXiv.2207.14729
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Manicka, S., Johnson, K., Levin, M., and Murrugarra, D. (2022), The nonlinearity of regulation in biological networks, bioRxiv, doi:10.1101/2021.12.22.473903
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McMillen, P., and Levin, M. (2022), Information Theory as an experimental tool for integrating disparate biophysical signaling modules, Preprints.org, doi:10.20944/preprints202207.0376.v1
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Pio-Lopez, L., Kuchling, F., Tung, A., Pezzulo, G., and Levin, M. (2022), Active Inference, Morphogenesis, and Computational Psychiatry, PsyArXiv, doi:10.31234/osf.io/4gp6c
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Pai, V. P., Cooper, B., and Levin, M. (2022), Screening biophysical sensors and actuators that influence wound healing in human induced pluripotent stem cell-derived neurons, Preprints.org, 2022070083, doi:10.20944/preprints202207.0083.v1
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Blackiston, D., Kriegman, S., Bongard, J., and Levin, M. (2022), Biological Robots: Perspectives on an Emerging Interdisciplinary Field, arXiv, doi:10.48550/arXiv.2207.00880
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Davies, J., and Levin, M. (2022), Synthetic Morphology via Active and Agential Matter, OSF Preprints, doi:10.31219/osf.io/xrv8h
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Levin, M. (2022), Collective Intelligence of Morphogenesis as a Teleonomic Process, PsyArXiv, doi:10.31234/osf.io/hqc9b
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Fields, C., and Levin, M. (2022), Competency in Navigating Arbitrary Spaces: Intelligence as an Invariant for Analyzing Cognition in Diverse Embodiments, PsyArxiv, doi:10.31234/osf.io/87nzu
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Novak, R., Lin, T., Kaushal, S., Sperry, M., Vigneault, F., Gardner, E., Loomba, S., Shcherbina, K., Keshari, V. , Dinis, A., Vasan, A., Chandrasekhar, V., Takeda, T., Turner, J. R., Levin, M., and Ingber, D. E. (2022), Target-agnostic discovery of Rett Syndrome therapeutics by coupling computational network analysis and CRISPR-enabled in vivo disease modeling, bioRxiv, doi:10.1101/2022.03.20.485056doi
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Hazan, H., Caby, S., Earl, C., Siegelmann, H., and Levin, M. (2022), Memory via Temporal Delays in weightless Spiking Neural Network, arXiv, doi:10.48550/arXiv.2202.07132
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Fields, C., Glazebrook, J. F., and Levin, M. (2022), Neurons as hierarchies of quantum reference frames, arXiv, doi:10.48550/arXiv.2201.00921
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Doctor, T., Witkowski, O., Solomonova, E., Duane, B., and Levin, M. (2022), Biology, Buddhism, and AI: Care as the Driver of Intelligence, MindRxiv, 10 Mar. 2022
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Levin, M. (2021), Technological Approach to Mind Everywhere (TAME): an experimentally-grounded framework for understanding diverse bodies and minds, PsyArXiv, doi:10.31234/osf.io/t6e8p
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Sperry, M., Novak, R., Keshari, V., Dinis, A. L. M., Cartwright, M. J., Camacho, D. M., Pare, J-F, Super, M., Levin, M., and Ingber, D. E. (2021), Enhancers of host immune tolerance to bacterial infection discovered using linked computational and experimental approaches, bioRxiv, doi:10.1101/2021.09.30.462576
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Levin, S. P., and Levin, M. (2021), Physarum polycephalum: Establishing an Assay for Testing Decision-making Under Shifting Somatic Boundaries, bioRxiv, doi:10.1101/2021.10.17.464734
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Payne, S. K., Ram, P., Srinivasan, D. H., Le, T. T., Levin, M., and Oudin, M. J. (2021), Potassium channel-driven bioelectric signaling regulates metastasis in triple-negative breast cancer, bioRxiv, doi:10.1101/2021.04.06.438714
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Fields, C., and Levin, M. (2021), Metabolic limits on classical information processing by biological cells, arXiv, doi:10.48550/arXiv.2103.17061
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Kriegman, S., Nasab, A. M., Blackiston, D., Steele, H., Levin, M., Kramer-Bottiglio, R., and Bongard, R. (2021), Scale invariant robot behavior with fractals, arXiv, doi:10.48550/arXiv.2103.04876
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Bischof, J., LaPalme, J., Miller, K., Morokuma, J., Williams, K., Fields, C., and Levin, M. (2021), Formation and Spontaneous Long-Term Repatterning of Headless Planarian Flatworms, bioRxiv, doi:10.1101/2021.01.15.426822
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Brodsky, M. (2020), Turing-like patterns can arise from purely bioelectric mechanisms, bioRxiv, doi:10.1101/336461
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Pentagna, N., Soares dos Santos, F., Martins de Almeida, F., Abreu, J. G., Levin, M., and Carneiro, K. (2020), Epigenetic immune-modulation by Histone Deacetylase Activity (HDAC) of tissue and organ regeneration in Xenopus laevis, bioRxiv, doi:10.1101/2020.02.05.936294
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Hazan, H., Levin, M. (2020), BindsNET – A Framework for Spiking Neuronal Simulation, Medium
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Hoel, E., Klein, B., Swain, A., Grebenow, R., Levin, M. (2020), Evolution leads to emergence: An analysis of protein interactomes across the tree of life, bioRxiv, doi:10.1101/2020.05.03.074419
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Murugan, N., Kaltman, D., Jin, H., Chien, M., Flores, R., Nguyen, C., Tuzoff, D., Minabutdinov, A., Kane, A., Novak, R., Ingber, D. (2020), Mechanosensation Mediates Long-Range Spatial Decision-Making in an Aneural Organism, bioRxiv, doi:10.1101/2020.03.20.985523
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Kriegman, S., Nasab, A. M., Shah, D., Steele, H., Branin, G., Levin, M., Bongard, J., and Kramer-Bottiglio, R. (2020), Scalable sim-to-real transfer of soft robot designs, arXiv, doi:10.48550/arXiv.1911.10290
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Reinmets, K., Bischof, J., Taketa, E., Levin, M., and Fuchs, S. M. (2020), S-adenosylhomocysteine hydrolase regulates anterior patterning in Dugesia japonica, bioRxiv, doi:10.1101/2020.01.22.916072
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Kriegman, S., Walker, S., Shah, D., Levin, M., Kramer-Bottiglio, R., and Bongard, J. (2019), Automated shapeshifting for function recovery in damaged robots, arXiv, doi:10.15607/RSS.2019.XV.028
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Manicka, S., and Levin, M. (2019), Modeling somatic computation with non-neural bioelectric networks, arXiv, doi:10.1038/s41598-019-54859-8
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Pezzulo, G., LaPalme, J., Durant, F., and Levin, M. (2019), Bistability of Somatic Pattern Memories: Stochastic Outcomes in Bioelectric Circuits Underlying Regeneration, Preprints.org, 2019110348
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Leigh, N. D., Sessa, S., Dragalzew, A. C., Payzin-Dogru, D., Sousa, J. F., Aggouras, A., Johnson, K., Dunlap, G. S., Haas, B. J., Levin, M., Schneider, I., and Whited, J. L. (2019), von Willebrand Factor D and EGF Domains is an evolutionarily conserved and required feature of blastemas capable of multi-tissue appendage regeneration, bioRxiv, doi:10.1101/842948
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Minh-Thai, T.N., Samarasinghe, S., and Levin, M. (2019), A comprehensive conceptual and computational dynamics framework for Autonomous Regeneration Systems, bioRxiv, doi:10.1101/820613
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Bischof, J., Day, M.E., Miller, K.A., LaPalme, J., and Levin, M. (2019), Nervous System and Tissue Polarity Dynamically Adapt to New Morphologies in Planaria, bioRxiv, doi:10.1101/815688
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Bonzanni, M., Payne, S. L., Adelfio, M., Kaplan, D. L., Levin, M., and Oudin, M. J. (2019), Defined extracellular ionic solutions to study and manipulate the cellular resting membrane potential, bioRxiv, doi 10.1101/785444
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Sullivan, K. G., Vandenberg, L. N., and Levin, M. (2018), Cellular Migration May Exhibit Intrinsic Left-Right Asymmetries: A meta-analysis, bioRxiv, doi:10.1101/052191
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Ferenc, N. N., and Levin, M. (2017), Effects of Ivermectin exposure on regeneration of D. dorotocephala planaria, bioRxiv, doi:10.1101/186650
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McDowell, G. S., Rajadurai, S., and Levin, M. (2016), From cytoskeletal dynamics to organ asymmetry: a non-linear, regulative pathway underlies left-right patterning, bioRxiv, doi:10.1101/052191
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