Image credit: after the Flammarion woodcut, by Jeremy Guay
Conceptual
quantitative enabling definitions of goal-directed activity and protocols for identifying and re-writing goals in vivo
continuum of agency (independent of substrate or origin story) - the TAME framework
observer-dependent models such as polycomputing
applications of paradigms such as active inference, causal information, and others for the cognitive light cone model
strategies for top-down control of (and communication with) cellular swarms
novel ethics frameworks for relating to diverse intelligences of unconventional composition and provenance
Computational
tools for AI-enabled bioinformatics of shape
software models of scaling of cognition across problem spaces
predictive environments for bioelectrical modeling
platforms for training pathways and inferring stimuli for GRN reprogramming
simulation frameworks for understanding how the process of natural evolution designs with agential materials
evolutionary models of scaling cognition, and of proto-cognitive competencies effects on evolutionary process
AI for design of biological robot properties
Biological
cracking the bioelectric code (mapping of voltage prepatterns to anatomical behaviors of cell groups)
investigating proto-cognitive capacities of biobots, chimeras, and hybrots
characterizing what cells and tissues can learn, and how that information moves throughout the body
characterizing generic, novel problem-solving abilities of evolution and its products (beyond direct selection)
identifying high-level triggers of morphogenetic subroutines for inducing complex regenerative outcomes
Biomedical
detecting, preventing, and reprogramming cancer bioelectrically
induction of limb and other organ regeneration
repair of birth defects using bioeletric strategy designed by computational platforms
design of stimuli for changing behaviors of transcriptional and other drug pathways in vivo
Engineering
novel biorobotics made of frog skin and other types of cells
new AI algorithms based on non-neural types of biological intelligence
living controllers for robots in 3D and other problem spaces
Wordcloud of the evolution of our papers over the last decades
"The law of the least action ... is a universal principle from which all other principles naturally flow" — Pierre de Maupertuis, 1750"
"The very same forces that "member" us, that place our heart and lungs and liver in relation to one another, that "organ"ize us into a decidedly human form, are now released to re-member, and to "organize" our life of memory." —Eugene Schwartz, quoting Rudolf Steiner
"The living organism represents, or occupies, a field of force which is never simple, and which as a rule is of immense
complexity." —D'Arcy Thompson (1917)
"Possibly the people who are trying to discover how to set up a computer to learn to play good chess, or bridge, are among
those most likely to make a major contribution to the fundamental theory of evolution." —Conrad Waddington (1968)