Peer-Reviewed Papers
Bioelectricity
Pio-Lopez, L., Levin, M. (2024), Aging as a loss of morphostatic information: a developmental bioelectricity perspective, Ageing Research Reviews, 2024, 97:102310
PDF
Balasubramanian, S., Weston, D., Levin, M., Davidian, D. C. C. (2024), Electroceuticals: emerging applications beyond the nervous system and excitable tissues, Trends Pharmacol Sci, 2024, 2109
PDF
Balasubramanian, S., Weston, D., Levin, M., Davidian, D. C. C. (2024), Charging Ahead: Examining the future therapeutic potential of electroceuticals, Advanced Therapeutics, 2024, 2300344
PDF
O’Brien, T., Stremmel, J., Pio-Lopez, L., McMillen, P., Rasmussen-Ivey, C., and Levin, M. (2024), Machine Learning for Hypothesis Generation in Biology and Medicine: Exploring the latent space of neuroscience and developmental bioelectricity, Digital Discovery, 3(2): 249-263
PDF
McMillen, P., and Levin, M. (2024), Optical Estimation of Bioelectric Patterns in Living Embryos, in M. Bizzarri (ed.), Systems Biology: Methods in Molecular Biology, 2745: 91-102, doi:10.1007/978-1-0716-3577-3_6
PDF
Manicka, S., Pai, V. P, and Levin, M. (2023), Information integration during bioelectric regulation of morphogenesis of the embryonic frog brain, iScience, 26(12): 108398
PDF
Blattner, M., and Levin, M. (2023) Long Range Communication via Gap Junctions and Stress in Planarian Morphogenesis: A Computational Study, Bioelectricity, 5(3): 196-209
PDF
Cervera, J., Levin, M., and Mafé, S. (2023), Correcting instructive electric potential patterns in multicellular systems: External actions and endogenous processes, Biochimica et Biophysica Acta (BBA) - General Subjects, 1867(10): 130440
PDF
Lagasse, E., and Levin, M. (2023), Future Medicine: from molecular pathways to the collective intelligence of the body, Trends in Molecular Medicine, 29(9): 687-710
PDF
Masuelli, S., Real, S., McMillen, P., Oudin, M., Levin, M., and Roqué, M. (2023), The Yin and Yang of Breast Cancer: Ion Channels as Determinants of Left-Right Functional Differences, International Journal of Molecular Sciences, 24(13): 11121
PDF
Cervera, J., Levin, M., and Mafé, S. (2023), Bioelectricidad en agregados multicelulares de células no excitables: modelos biofísicos, Revista Española de Física, 37(2): 24-29
Levin, M. (2023), Bioelectric networks: the cognitive glue enabling evolutionary scaling from physiology to mind, Animal Cognition, doi:10.1007/s10071-023-01780-3
PDF
Pio-Lopez, L., and Levin, M. (2023), Morphoceuticals: Perspectives for discovery of drugs targeting anatomical control mechanisms in regenerative medicine, cancer and aging, Drug Discovery Today, 28(6): 103585
PDF
Davies, J., and Levin, M. (2023), Synthetic morphology with agential materials, Nature Reviews Bioengineering, 1(1): 46-59
PDF
Cervera, J., Levin, M., and Mafe, S. (2023), Bioelectricity of non-excitable cells and multicellular pattern memories: Biophysical modeling, Physics Reports, 1004: 1-31, doi:10.1016/j.physrep.2022.12.003
PDF
Hazan, H., and Levin, M. (2022), Exploring the Behavior of Bioelectric Circuits Using Evolution Heuristic Search, Bioelectricity, 4(4): 207-227
PDF
Dechiraju, H., Selberg, J., Jia, M., Pansodtee, P., Li, H., Hsieh, H-C., Hernandez, C., Asefifeyzabadi, N., Nguyen, T., Baniya, P., Marquez, G., Rasmussen-Ivey, C., Bradley, C., Teodorescu, M., Gomez, M., Levin, M., and Rolandi, M. (2022), On-chip on-demand delivery of K+ for in vitro bioelectronics, AIP Advances, 12(12): 125205
PDF
Cervera, J., Manzanares, J. A., Levin, M., and Mafe, S. (2022), Transplantation of fragments from different planaria: a bioelectrical model for head regeneration, Journal of Theoretical Biology, 558: 111356
PDF
Pai, V. P., Cooper, B. G., and Levin, M. (2022), Screening Biophysical Sensors and Neurite Outgrowth Actuators in Human Induced-Pluripotent-Stem-Cell-Derived Neurons, Cells, 11(16): 2470
PDF
Pai, V. P., and Levin, M. (2022), HCN2 Channel-induced Rescue of Brain, Eye, Heart, and Gut Teratogenesis Caused by Nicotine, Ethanol, and Aberrant Notch Signaling, Wound Repair and Regeneration, 30(6): 681-706
PDF
Mathews, J., Kuchling, F., Baez-Nieto, D., Diberardinis, M., Pan, J. Q., and Levin, M. (2022), Ion Channel Drugs Suppress Cancer Phenotype in NG108-15 and U87 Cells: Toward Novel Electroceuticals for Glioblastoma, Cancers 14(6): 1499
PDF
Grodstein, J., and Levin, M. (2022), A Computational Approach to Explaining Bioelectrically-induced Persistent, Stochastic Changes of Axial Polarity in Planarian Regeneration, Bioelectricity, 4(1): 18-30
PDF
Adelfio, M., Bonzanni, M., Levin, M., and Kaplan, D. L. (2022), Impact of Membrane Voltage on Formation and Stability of Human Renal Tubules in Vitro, ACS Biomaterials Science & Engineering, 8(3): 1239-1246
PDF
Masuelli, S., Sebastian, R., Campoy, E., Branham, M. T., Marzese, D. M., Matthew, S., DeBlas, G., Rodolfo, A., Levin, M., and Roque, M. (2022), When left does not seem right: epigenetic and bioelectric differences between left-and right-sided breast cancer, Molecular Medicine, 28(1): 15
PDF
Manicka, S., and Levin, M. (2022), Minimal developmental computation: a causal network
approach to understand morphogenetic pattern formation,
Entropy, 24: 107
PDF
Payne, S. L., Ram, P., Srinivasan, D. H., Le, T. T., Levin, M., and Oudin, M. J. (2021), Potassium channel-driven bioelectric signalling regulates metastasis in triple-negative breast cancer, EBioMedicine, 75: 103767
PDF
Riol, A., Cervera, J., Levin, M., and Mafe, S. (2021), Cell Systems Bioelectricity: How Different Intercellular Gap Junctions Could Regionalize a Multicellular Aggregate,
Cancers, 13(21): 5300
PDF
Grodstein, J., and Levin, M. (2021), Stability and robustness properties of bioelectric networks: A computational approach,
Biophysics Review, 2: 031305
PDF
Levin, M. (2021), Bioelectrical approaches to cancer as a
problem of the scaling of the cellular self,
Progress in Biophysics and Molecular Biology, 165: 102-113
PDF
Cervera, J., Levin, M., and Mafe, S. (2021), Morphology changes induced by intercellular
gap junction blocking: a reaction-diffusion mechanism, BioSystems, 209: 104511
PDF
Levin, M. (2021), Bioelectric Signaling: Reprogrammable Circuits
Underlying Embryogenesis, Regeneration, and Cancer, Cell, 184(8): 1971-1989
PDF
Nanos, V., and Levin, M. (2021), Rewiring Endogenous Bioelectric Circuits in the Xenopus laevis Embryo Model, in M. R. Ebrahimkhani and J. Hislop (Eds.), Programmed Morphogenesis: Methods in Molecular Biology, 2258: 93-103
PDF
Srivastava, P., Kane, A., Harrison, C., and Levin, M. (2021), A Meta-Analysis of Bioelectric Data in Cancer, Embryogenesis, and Regeneration, Bioelectricity, 3(1): 42-67
PDF
Pezzulo, G., Lapalme, J., Durant, F., and Levin, M. (2021), Bistability of Somatic Pattern Memories: Stochastic Outcomes in Bioelectric Circuits Underlying Regeneration,
Philosophical Proceedings of the Royal Society B, 376(1821): 20190765
PDF
Cervera, J., Ramirez, P., Levin, M., and Mafe, S. (2020), Community effects allow bioelectrical reprogramming of cell membrane potentials in multicellular aggregates: Model simulations, Physical Review E, 102(5): 052412
PDF
Sousounis, K., Erdogan, B., Levin, M., and Whited, J. L. (2020), Precise control of
ion channel and gap junction expression is required for patterning of the regenerating axolotl limb, International Journal of Developmental Biology, 64(10-11-12): 485-494
PDF
Erndt-Marino, J., Yeisley, D. J., Chen, H., Levin, M., Kaplan, D. L., and Hahn, M. S. (2020), Interferon-Gamma Stimulated Murine Macrophages In Vitro: Impact of Ionic Composition and Osmolarity and Therapeutic Implications, Bioelectricity, 2(1): 48-58
PDF
Leronni, A., Bardella, L., Dorfmann, L., Pietak, A., and Levin, M. (2020), On the coupling of mechanics with bioelectricity and its role in morphogenesis, Journal of the Royal Society Interface, 17(167): 20200177
PDF
Pai, V., Cervera, J., Mafe, S., Willocq, V., Lederer, E., and Levin, M. (2020), HCN2 Channel-induced Rescue of Brain Teratogenesis via local and long-range bioelectric repair, Frontiers in Cellular Neuroscience, 14: 136
PDF
Cervera, J., Levin, M., and Mafe, S. (2020), Bioelectrical Coupling of Single-Cell States in Multicellular Systems, Journal of Physical Chemistry Letters, 11(9): 3234-3241
PDF
Levin, M. (2020), Revisiting Burr and Northrop's 'The Electro-Dynamic Theory of Life', Biological Theory, 15: 83-90
PDF
McMillen, P., Novak, R., and Levin, M. (2020), Toward Decoding Bioelectric Events in
Xenopus Embryogenesis: New Methodology for Tracking Interplay Between Calcium and Resting Potentials In Vivo, Journal of Molecular Biology, 432(2): 605-620
PDF
Kamaldinov, T., Erndt-Marino, J., Levin, M., Kaplan, D. L., and Hahn, M. S. (2020), Assessment of Enrichment of Human Mesenchymal Stem Cells Based on Plasma and Mitochondrial Membrane Potentials, Bioelectricity,
PDF
Healy, D., Faber, C., Lapalme, J., and Levin, M. (2020), Post-SSRI Sexual Dysfunction:
a bioelectric mechanism?, Bioelectricity,
PDF
Levin, M. (2020), The Biophysics of Regenerative Repair Suggests New Perspectives on Biological Causation, BioEssays, 42(2): 1900146
PDF
Cervera, J., Meseguer, S., Levin, M., and Mafe, S. (2020), Bioelectrical model of head-tail patterning
based on cell ion channels and intercellular gap junctions, Bioelectrochemistry, 132: 107410
PDF
Levin, M., Selberg, J., and Rolandi, M. (2019), Endogenous Bioelectrics in Development,
Cancer, and Regeneration: Drugs and Bioelectronic Devices as Electroceuticals for Regenerative Medicine,
iScience, 22: 519-533
PDF
Fields, C., Bischof, J., and Levin, M. (2020), Morphological Coordination:
A Common Ancestral Function Unifying Neural and Non-Neural Signaling,
Physiology, 35: 16-30
PDF
Bonzanni, M., Payne, S. L., Adelfio, M., Kaplan, D. L., Levin, M., and Oudin, M. J. (2020),
Defined extracellular ionic solutions to study and manipulate the cellular resting membrane potential, Biology Open, 9(1): bio048553
PDF
Manicka, S., and Levin, M. (2019), Modeling somatic computation with non-neural bioelectric networks, Scientific Reports, 9: 18612
PDF
Levin, M. (2019), The Computational Boundary of a "Self":
developmental bioelectricity drives multicellularity and scale-free cognition,
Frontiers in Psychology, 10:2688, doi: 10.3389/fpsyg.2019.02688
PDF
Emmons-Bell, M., Durant, F., Tung, A., Pietak, A., Miller, K., Kane, A., Martyniuk, C. J.,
Davidian, D., Morokuma, J., and Levin, M. (2019),
Regenerative Adaptation To Electrochemical Perturbation In Planaria: A Molecular Analysis
Of Physiological Plasticity, iScience, 22: 147-165
PDF
Atsuta, Y., Tomizwa, R. R., Levin, M., and Tabin, C. J. (2019), L-type voltage-gated Ca2+
channel CaV1.2 regulates chondrogenesis during limb development, Proceedings of the National Academy
of Sciences of the United States, 116(43): 21592-21601
PDF
Payne, S. L., Levin, M., and Oudin, M. J. (2019), Bioelectric control of metastasis in
solid tumors, Bioelectricity, 1(3): 114-130
PDF
Whited, J., and Levin, M. (2019), Bioelectrical controls of morphogenesis: from ancient mechanisms of
cell coordination to biomedical opportunities, Current Opinion in Genetics & Development, 57: 61-69
PDF
Cervera, C., Pai, V. P., Levin, M., and Mafe, S. (2019),
From non-excitable single-cell to multicellular bioelectrical states
supported by ion channels and gap junction proteins: electrical potentials
as distributed controllers, Progress in Biophysics and Molecular Biology, 149: 39-53
PDF
Cervera, J., Manzanares, J. A., Mafe, S., and Levin, M. (2019), Synchronization of Bioelectric Oscillations in Networks of Nonexcitable Cells: From Single-Cell to Multicellular States, Journal of Physical Chemistry B, 123(18): 3924-3934
PDF
Sundelacruz, S., Moody, A. T., Levin, M., and Kaplan, D. (2019), Membrane potential depolarization
alters calcium flux and phosphate signaling during osteogenic differentiation of human mesenchymal stem cells,
Bioelectricity, 1(1): 56-66
PDF
Ferenc, N. N., and Levin, M. (2019), Effects of ivermectin exposure on regeneration of
D. dorotocephala planaria: exploiting human-approved ion channel drugs as morphoceuticals, Macromolecular Bioscience, 19(3): 1800237
PDF
Durant, F., Bischof, J., Fields, C., Morokuma, J., LaPalme, J., Hoi, A., and Levin, M. (2019), The role of early bioelectric signals in the regeneration of planarian anterior/posterior polarity, Biophysical Journal, 116(5): 948-961
PDF
Churchill, C. D. M., Winter, P., Tuszynski, J. A., and Levin, M. (2019), EDEn - Electroceutical Design Environment: An Ion Channel Database with Small Molecule Modulators, iScience, 11: 42-56
PDF
Cairns, D. M., Giordano, J. E., Conte, S., Levin, M., and Kaplan, D. L. (2018),
Ivermectin promotes peripheral nerve regeneration during wound healing,
ACS Omega, 3(10): 12392-12402
PDF
Busse, S. M., McMillen, P. T., and Levin, M. (2018), Cross-limb Communication During Xenopus Hind-limb Regenerative Response: Non-Local Bioelectric Injury Signals,
Development, 145(19): dev164210
PDF
Ferreira, G. B. S., Scheutz, M., and Levin, M. (2018), Modeling Cell Migration in a Simulated Bioelectrical Signaling Network for Anatomical Regeneration, in T. Ikegami, N. Virgo, O. Witkowski, M. Oka, R. Suzuki and H. Iizuka (Eds.), ALIFE 2018: The 2018 Conference on Artificial Life. MIT Press: Tokyo,
PDF
Brodsky, M., and Levin, M. (2018), From Physics to Pattern: Uncovering Pattern Formation in Tissue Electrophysiology, in T. Ikegami, N. Virgo, O. Witkowski, M. Oka, R. Suzuki and H. Iizuka (Eds.), ALIFE 2018: The 2018 Conference on Artificial Life. MIT Press: Tokyo,
PDF
Cervera, J., Pietak, A., Levin, M., and Mafe, S. (2018), Bioelectrical coupling in multicellular
domains regulated by gap junctions: a conceptual approach, Bioelectrochemistry, 123: 45-61
PDF
Pietak, A., and Levin, M., (2018), Bioelectrical control of positional information in
development and regeneration: a review of conceptual and computational advances,
Progress in Biophysics and Molecular Biology, 137: 52-68
PDF
Mathews, J., and Levin, M. (2018), The Body Electric 2.0: Recent Advances in Developmental
Bioelectricity for Regenerative and Synthetic Bioengineering,
Current Opinion in Biotechnology, 52: 134-144
PDF
Pai, V. P., Pietak, A., Willocq, V., Ye, B., Shi, N-Q., and Levin, M. (2018),
HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns,
Nature Communications, 9(1): 998
PDF
Levin, M., and Martyniuk, C. J. (2018), The bioelectric code: An ancient computational medium
for dynamic control of growth and form, BioSystems, 164: 76-93
PDF
Herrera-Rincon, C., and Levin, M. (2018), Booting up the organism during
development: pre-behavioral functions of the vertebrate brain in guiding body morphogenesis,
Communicative & Integrative Biology, 11(1): e1433440
PDF
Pitcairn, E., Harris, H., Epiney, J., Pai, V. P., Lemire, J. M., Ye, B., Shi, N-Q., Levin, M., and McLaughlin, K. A. (2017),
Coordinating heart morphogenesis: A novel role for Hyperpolarization-activated cyclic nucleotidegated
(HCN) channels during cardiogenesis in Xenopus laevis, Communicative & Integrative Biology, 10(3): e1309488
PDF
Pietak, A. M., and Levin, M. (2017), Bioelectric Gene and Reaction Networks: Computational Modeling of Genetic, Biochemical, and Bioelectrical Dynamics in Pattern Regulation, Journal of the Royal Society Interface, 14(134): 20170425
PDF
McLaughlin, K. A., and Levin, M. (2017), Bioelectric Signaling in Regeneration:
Mechanisms of Ionic Controls of Growth and Form, Developmental Biology, 433(2): 177-189
PDF
Pai, V. P., Willocq, V., Pitcairn, E. J., Lemire, J. M., Paré, J-F., Shi, N-Q., McLaughlin, K. A., and Levin, M. (2017),
HCN4 Ion Channel Function is Required for Early Events that Regulate Anatomical Left-Right Patterning in
a Nodal- and Lefty Asymmetric gene Expression-Independent Manner, Biology Open, 6(10): 1445-1457
PDF
Adams, D. S., Tseng, A-S., and Levin, M. (2017), Using optogenetics in vivo to stimulate regeneration, in K. Appasani (Ed.), Optogenetics: From Neuronal Function to Mapping and Disease Biology. Cambridge University Press: Cambridge, UK, p. 66-76
Dungan, J., Mathews, J., Levin, M., and Koomson, V. (2017), Microfluidic Platform to Study Intercellular Connectivity Through on-Chip Electrical Impedance Measurement, IEEE 60th International Midwest Symposium on Circuits and Systems, Boston, MA, p. 56-69
PDF
Paré, J-F., Martyniuk, C. J., and Levin, M. (2017), Bioelectric regulation of innate immune system function in regenerating and intact Xenopus laevis, npj Regenerative Medicine, 2: 15
PDF
Durant, F., Morokuma, J., Fields, C., Williams, K., Adams, D. S., and Levin, M. (2017),
Long-Term, Stochastic Editing of Regenerative Anatomy via Targeting Endogenous
Bioelectric Gradients, Biophysical Journal, 112(10): 2231-2243
PDF
Mathews, J., and Levin, M. (2017), Gap Junctional Signaling in Pattern Regulation:
physiological network connectivity instructs growth and form, Developmental Neurobiology, 77(5): 643-673
PDF
Levin, M., Pezzulo, G., and Finkelstein, J. M. (2017), Endogenous Bioelectric
Signaling Networks: Exploiting Voltage Gradients for Control of Growth and Form,
Annual Review of Biomedical Engineering, 19: 353-387
PDF
Thurber, A. E., Nelson, M., Frost, C. L., Levin, M., Brackenbury, W. J., and Kaplan D. L. (2017),
IK channel activation increases tumor growth and induces differential behavioral
responses in two breast epithelial cell lines, Oncotarget, 8(26): 42382-42397
PDF
Lobo, D., Lobikin, M., and Levin, M. (2017), Discovering novel phenotypes with automatically
inferred dynamic models: partial melanocyte conversion in Xenopus,
Scientific Reports, 7: 41339
PDF
Pezzulo, G., and Levin, M. (2016), Top-down models in biology: explanation and control
of complex living systems above the molecular level, Journal of the Royal Society Interface, 13(124): 20160555
PDF
Herrera-Rincon, C., Guay, J., and Levin, M. (2016), Bioelectrical coordination
of cell activity toward anatomical target states: an engineering perspective on regeneration,
Chapter 4 in D. Gardiner (Ed.), Regenerative Engineering and Developmental Biology: Principles and Applications,
CRC Press: Boca Raton, FL, p. 55-112
Link
Pietak, A., and Levin, M. (2016), Exploring Instructive Physiological Signaling with
the Bioelectric Tissue Simulation Engine , Frontiers in Bioengineering and Biotechnology, 4: (55)
PDF
Pai, V. P., Martyniuk, C. J., Echeverri, K., Sundelacruz, S., Kaplan, D. L., and Levin, M. (2016), Genome-wide analysis reveals conserved transcriptional responses downstream of resting potential change in Xenopus embryos, axolotl regeneration, and human mesenchymal cell differentiation, Regeneration, 3(1): 3-25
PDF
Sullivan, K. G., Emmons-Bell, M., and Levin, M. (2016), Physiological Inputs Regulate
Species-Specific Anatomy During Embryogenesis And Regeneration, Communicative & Integrative Biology, 9(4): e1192733
PDF
Durant, F., Lobo, D., Hammelman, J., and Levin, M. (2016), Physiological controls of
large-scale patterning in planarian regeneration: a molecular and computational
perspective on growth and form, Regeneration, 3(2): 78-102
PDF
Chernet, B. T., Adams, D. S., Lobikin, M., and Levin, M. (2016),
Use of genetically encoded, light-gated ion translocators to control tumorigenesis,
Oncotarget, 7(15): 19575-19588
PDF
Adams, D. S., Uzel, S. G. M., Akagi, J., Wlodkowic, D., Andreeva, V., Yelick, P. C., Devitt-Lee, A., Paré, J-F., and Levin, M. (2016), Bioelectric signaling via potassium channels: a mechanism
for craniofacial dysmorphogenesis in KCNJ2-associated Andersen-Tawil Syndrome, Journal of Physiology, 594(12): 3245-3270
PDF
Li, C., Levin, M., and Kaplan, D. (2016), Bioelectric modulation of macrophage polarization, Scientific Reports, 6: 21044
PDF
Sundelacruz, S., Levin M., and Kaplan, D. L. (2015), Comparison of the depolarization response of human mesenchymal stem cells from different donors, Scientific Reports, 5: 18279
PDF
Emmons-Bell, M., Durant, F., Hammelman, J., Bessonov, N., Volpert, V., Morokuma, J., Pinet, K., Adams, D. S., Pietak, A., Lobo, D., and Levin, M. (2015), Gap junctional blockade stochastically induces different species-specific head anatomies in genetically wild-type Girardia
dorotocephala flatworms, International Journal of Molecular Sciences, 16(11): 27865-27896
PDF
Pezzulo, G., and Levin, M. (2015), Re-membering the body: applications of computational
neuroscience to the top-down control of regeneration of limbs and other complex organs,
Integrative Biology, 7(12): 1487-1517
PDF
Lobikin, M., Lobo, D., Blackiston, D. J., Martyniuk, C. J., Tkachenko, E., and Levin, M. (2015),
Serotonergic regulation of melanocyte conversion: A bioelectrically regulated network
for stochastic all-or-none hyperpigmentation, Science Signaling, 8(397): ra99
PDF
Law, R., and Levin, M. (2015), Bioelectric memory: modeling resting potential bistability in amphibian embryos and mammalian cells, Theoretical Biology and Medical Modelling, 12(1): 22
PDF
Schatzberg, D., Lawton, M., Hadyniak, S. E., Ross E. J., Carney, T., Beane, W. S., Levin, M., and Bradham, C. A. (2015), H+/K+-ATPase activity is required for biomineralization in sea urchin embryos, Developmental Biology, 406(2): 259-270
PDF
Pai, V. P., Lemire, J. M., Chen, Y., Lin, G., and Levin, M. (2015), Local and long-range
endogenous resting potential gradients antagonistically regulate apoptosis and proliferation
in the embryonic CNS, International Journal of Developmental Biology, 59(7-9): 327-340
PDF
Lobikin, M., Paré, J-F., Kaplan, D. L., and Levin, M. (2015), Selective Depolarization Of Transmembrane Potential Alters Muscle Patterning And Muscle Cell Localization In Embryonic Xenopus Laevis, International Journal of Developmental Biology, 59(7-9): 303-311
PDF
Pai, V., Lemire, J. M., Paré, J-F., Lin, G., Chen, Y., and Levin, M. (2015), Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation, Journal of Neuroscience, 35(10): 4366-4385
PDF
Blackiston, D., Anderson, G. M., Rahman, N., Bieck, C., and Levin, M. (2015), A novel method for inducing nerve growth via modulation of host resting potential, Neurotherapeutics, 12(1): 170-184
PDF
Chernet, B. T., Fields, C., and Levin, M. (2015), Long-range gap junctional signaling
controls oncogene-mediated tumorigenesis in Xenopus laevis embryos, Frontiers in Physiology, 5: 519
PDF
Özkucur, N., Quinn, K. P., Pang, J. C., Du, C., Georgakoudi, I., Miller, E., Levin, M., and Kaplan, D. L. (2015), Membrane potential depolarization causes alterations in neuron arrangement and connectivity in cocultures, Brain and Behavior, 5(1): 24-38
PDF
Levin, M. (2014), Molecular bioelectricity: how endogenous voltage potentials control cell behavior
and instruct pattern regulation in vivo, Molecular Biology of the Cell, 25(24): 3835-3850
PDF
Adams, D. S., Lemire, J. M., Kramer, R. H., and Levin, M. (2014), Optogenetics in developmental biology: using light to control ion flux-dependent signals in Xenopus embryos, International Journal of Developmental Biology, 58(10-12): 851-861
PDF
Lan, J. Y., Williams, C., Levin, M., and Black, L. D. III (2014), Depolarization of Cellular Resting Membrane Potential Promotes Neonatal Cardiomyocyte Proliferation In Vitro, Cellular and Molecular Bioengineering, 7(3): 432-445
PDF
Mustard, J., and Levin, M. (2014), Bioelectrical mechanisms for programming
growth and form: taming physiological networks for soft body robotics, Soft Robotics, 1(3): 169-191
PDF
Chernet, B., and Levin, M. (2014), Transmembrane voltage potential of
somatic cells controls oncogene-mediated tumorigenesis at long-range,
Oncotarget, 5(10): 3287-3306
PDF
Hernandez-Diaz, S., and Levin, M. (2014), Alteration of bioelectrically-controlled processes
in the embryo: a teratogenic mechanism for anticonvulsants, Reproductive Toxicology, 47: 111-114
PDF
Levin, M. (2014), Endogenous bioelectrical networks store non-genetic patterning information during development and regeneration, Journal of Physiology, 592(11): 2295-2305
PDF
Pai, V., and Levin, M. (2014), Bioelectric controls of stem cell function, Chapter 5 in F. Calegari and C. Waskow (Eds.), Stem Cells: From Basic Research to Therapy, Volume 1, CRC Press: Boca Raton, FL, pp. 106-148
Amazon book
Lobikin, M., and Levin, M. (2014), Endogenous bioelectric cues as morphogenetic signals in vivo, Chapter 15 in D. Fels, M. Cifra, and F. Scholkmann (Eds), Fields of the Cell, Research Signpost: Kerala, India, pp. 283-302
PDF
Lange, C., Prenninger, S., Knuckles, P., Taylor, V., Levin, M., and Calegari, F. (2014), V-ATPase maintains neural stem cells in the developing mouse cortex, in S. Nakamuri (Ed.), Handbook of H+ ATPases, Pan Stanford Pte. Ltd: Singapore, pp. 413-430
PDF
Sundelacruz, S., Li, C., Choi, Y. J., Levin, M., and Kaplan, D. L. (2013), Bioelectric
modulation of wound healing in a 3D in vitro model of tissue-engineered bone,
Biomaterials, 34(28): 6695-705
PDF
Sundelacruz, S., Levin, M., and Kaplan, D. L. (2013), Depolarization Alters Phenotype, Maintains Plasticity of Predifferentiated Mesenchymal Stem Cells,Tissue Engineering Part A, 19(17-18): 1889-1908
PDF
Chernet, B., and Levin, M. (2013), Endogenous voltage potentials and
the microenvironment: bioelectric signals that reveal, induce, and normalize cancer,
Journal of Clinical and Experimental Oncology, S1: doi:10.4172/2324-9110.S1-002
PDF
Levin, M. (2013), Reprogramming cells and tissue
patterning via bioelectrical pathways: molecular mechanisms
and biomedical opportunities, Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 5(6): 657-676
PDF
Levin, M. (2013), Bioelectrical signaling has rich history, Physics Today, 66(9): 11
PDF
Adams, D. S., and Levin, M. (2013), Endogenous Voltage Gradients as Mediators of Cell-Cell Communication: Strategies for Investigating Bioelectrical Signals During Pattern Formation, Cell and Tissue Research, 352(1):95-122
PDF
Chernet, B. T., and Levin, M. (2013), Transmembrane voltage potential is an essential cellular parameter for the detection and control of tumor development in a Xenopus model,
Disease Models & Mechanisms, 6(3): 595-607
PDF
Beane, W. S., Morokuma, J., Lemire, J. M., and Levin, M. (2013),
Bioelectric signaling regulates head and organ size during planarian regeneration,
Development, 140(2): 313-322
PDF
Tseng, A-S., and Levin, M. (2013), Cracking the
bioelectric code: probing endogenous ionic controls of pattern
formation, Communicative & Integrative Biology,
6(1): e22595
PDF
Adams, D. S., Tseng, A-S. and Levin, M. (2013), Light-activation of the Archaerhodopsin
H+ pump reverses age-dependent loss of vertebrate regeneration: sparking system-level
controls in vivo, Biology Open, 2(3): 306-313
PDF
Pai, V. P., Vandenberg, L. N., Blackiston, D. J., and Levin, M. (2012), Neurally derived tissues in Xenopus laevis embryos exhibit a consistent bioelectrical left-right asymmetry, Stem Cells International, 2012: 353491
PDF
Lobikin, M., Chernet, B., Lobo, D., and Levin, M. (2012),
Resting potential, oncogene-induced tumorigenesis, and
metastasis: the bioelectric basis of cancer in vivo,
Physical Biology, 9(6): 065002
PDF
Tseng, A.-S., and Levin, M. (2012), Transducing bioelectrical signals into
epigenetic pathways during tadpole tail regeneration,
Anatomical Record, 295(10): 1541-1551
PDF
Levin, M., and Stevenson, C. (2012), Regulation of Cell
Behavior and Tissue Patterning by Bioelectrical Signals: challenges and
opportunities for biomedical engineering, Annual Reviews in
Biomedical Engineering, 14: 295-323
PDF
Adams, D. S., and Levin, M. (2012),
General principles for measuring resting
membrane potential and ion concentration using fluorescent bioelectricity
reporters, Cold Spring Harbor Protocols, 2012(4): 385-397
PDF
Adams, D. S., and M. Levin (2012), Measuring resting membrane potential using the fluorescent voltage reporters
PDF
Levin, M. (2012), Molecular bioelectricity in developmental biology: new
tools and recent discoveries, BioEssays, 34(3): 205-217
PDF
Pai, V., Aw, S., Shomrat, T., Lemire, J. M., and Levin, M. (2012), Transmembrane
voltage potential controls embryonic eye patterning in Xenopus laevis,
Development, 139(2): 313-323
PDF
Blackiston, D., Adams, D. S., Lemire, J. M., Lobikin, M., and Levin, M. (2011),
Transmembrane potential of GlyCl-expressing instructor cells induces a neoplastic-like conversion of
melanocytes via a serotonergic pathway, Disease Models and Mechanisms, 4(1): 67-85
PDF
Beane, W. S., Morokuma, J., Adams, D. S., and Levin, M. (2011),
A chemical genetics approach reveals H,K-ATPase-mediated
membrane voltage is required for planarian head regeneration,
Chemistry & Biology,
PDF
Lange, C., Prenninger, S., Knuckles, P., Taylor, V., Levin, M., and
Calegari, F. (2011), The H(+) vacuolar ATPase maintains neural stem cells in the developing
mouse cortex, Stem Cells
and Development, 20(5): 843-850
PDF
Levin, M. (2011), Endogenous Bioelectric Signals as Morphogenetic Controls of Development, Regeneration, and Neoplasm, in C. Pullar (Ed.), The Physiology of Bioelectricity in
Development, Tissue Regeneration, and Cancer, CRC Press: Boca Raton, FL, pp. 39-89
Available here
Levin, M. (2011), The wisdom of the body: future techniques and approaches to morphogenetic fields in regenerative medicine, developmental biology, and cancer, Regenerative Medicine, 6(6): 667-673
PDF
Aw, S., Koster, J., Pearson, W., Nicols, C., Shi, N. Q., Carneiro, K., and Levin, M. (2010), The ATP-sensitive K+-channel (KATP) controls early left-right patterning in Xenopus and chick embryos, Developmental Biology, 346(1): 39-53
PDF
Tseng, A-S., Beane, W. S., Lemire, J. M., Masi, A., and Levin, M. (2010),
Induction of vertebrate regeneration by a transient sodium current,
Journal of Neuroscience, 30(39): 13192-13200
PDF
Zhang, Y., and Levin, M. (2009), Particle tracking model of electrophoretic
morphogen movement reveals stochastic dynamics of embryonic gradient,
Developmental Dynamics, 238(8): 1923-1935
PDF
Levin, M. (2009), Bioelectric mechanisms in regeneration: Unique aspects and future perspectives, Seminars in Cell and Developmental Biology, 20(5): 543-556
PDF
Sundelacruz, S., Levin M., and Kaplan, D. L. (2009), Role of membrane potential in the regulation of cell proliferation and differentiation, Stem Cell Reviews, 5(3): 231-246
PDF
Blackiston, D. J., McLaughlin, K., and Levin, M. (2009), Bioelectric
controls of cell proliferation: ion channels, membrane voltage, and the cell
cycle, Cell Cycle, 8(21): 3527-3536
PDF
Morokuma, J., Blackiston, D., and Levin, M. (2008), KCNQ1 and KCNE1 K+ channel components are involved in early left-right patterning in Xenopus embryos, Cellular Physiology and Biochemistry, 21(5-6): 357-372
PDF
Morokuma, J., Blackiston, D., Adams, D. S., Seebohm, G., Trimmer, B., and Levin, M. (2008), Modulation of potassium channel confers a hyperproliferative invasive phenotype on embryonic stem cells, Proceedings of the National Academy of Sciences of the United States, 105(43): 16608-16613
PDF
Sundelacruz, S., Levin, M., and Kaplan, D. L. (2008), Membrane potential controls adipogenic and osteogenic differentiation of mesenchymal stem cells, PLoS One, 3(11): e3737
PDF
Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M. (2008), Live imaging of planarian membrane potential using DiBAC4(3), Cold Spring Harbor Protocols, 3(10): pdb.prot5055
PDF
Adams, D. S., Masi, A., and Levin, M. (2007), H+ Pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration, Development, 134(7): 1323-1335
PDF
Aw, S., Adams, D. S., Qiu, D., and Levin, M. (2007), H,K-ATPase protein localization and Kir4.1 function reveal concordance of three axes during early determination of left-right
asymmetry, Mechanisms of Development, 125(3-4): 353-372
PDF
Levin, M. (2007), Large-Scale Biophysics: Ion Flows and Regeneration, Trends in Cell Biology, 17(6): 261-270
PDF
Hibino, T., Ishii, Y., Levin, M., and Nishino, A. (2006), Ion flow regulates left-right asymmetry in sea urchin development, Development Genes and Evolution, 216(5): 265-76
PDF
Shimeld, S. M., and Levin, M. (2006), Evidence for the regulation of left-right asymmetry in Ciona intestinalis by ion flux, Developmental Dynamics, 235(6): 1543-1553
PDF
Adams, D. S., Robinson, K. R., Fukumoto, T., Yuan, S., Albertson, R. C., Yelick, P., Kuo, L., McSweeney, M., and Levin, M. (2006), Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates, Development, 133(9): 1657-1671
PDF
Esser, A. T., Smith, K. C., Weaver, J. C., and Levin, M. (2006), Mathematical Model of Morphogen Electrophoresis through Gap Junctions, Developmental Dynamics, 235(8): 2144-2159
PDF
Adams, D. S., and Levin, M. (2006), Inverse Drug Screens: a rapid and inexpensive method for implicating molecular targets, Genesis, 44(11): 530-540
PDF
Adams, D., and Levin, M. (2006), Strategies and techniques for investigation of biophysical signals in patterning, in Analysis of Growth Factor signaling in Embryos, M. Whitman and A. K. Sater eds., pp. 177-264, Methods in Signal Transduction Series, CRC Press
Levin, M. (2003), Bioelectromagnetics in morphogenesis,
Bioelectromagnetics, 24(5): 295-315
PDF
Levin, M. (2003), Motor protein control of ion flux is an early step in embryonic
Left-Right asymmetry, BioEssays, 25(10): 1002-1010
PDF
Levin, M., Thorlin, T., Robinson, K., Nogi, T., and Mercola, M. (2002),
Asymmetries in H+/K+-ATPase and cell membrane potentials comprise
a very early step in left-right patterning,
Cell, 111(1): 77-89
PDF
Rutenberg, J., Cheng, S. M., and Levin, M. (2002), Early embryonic expression
of ion channels and pumps in chick and Xenopus development,
Developmental Dynamics, 225(4): 469-484
PDF
Cheng, S. M., Chen, I., and Levin, M. (2002), Katp channel activity is required
for hatching in Xenopus embryos, Developmental Dynamics, 225(4): 588-591
PDF
Levin, M., (1999), Endogenous electromagnetic fields and radiations in regeneration, development, and neoplasm, Proceedings of the First World Congress on the Effects of Electricity and Magnetism in the Natural World, Madeira, Portugal
Levin, M., and Ernst, S. G. (1997), Applied DC magnetic fields
cause alterations in the time of cell divisions and developmental abnormalities
in early sea urchin embryos, Bioelectromagnetics, 18(3): 255-263
PDF
Levin, M., and Ernst, S. G. (1995), Applied AC and DC Magnetic Fields
Cause Alterations in the Mitotic Cycle of Early Sea Urchin Embryos,
Bioelectromagnetics, 16(4): 231-240
PDF
Levin, M. (1993), Current and potential applications of bioelectromagnetics in medicine, Subtle Energies & Energy Medicine Journal, 4(1): 77-87
PDF
