Peer-Reviewed Papers
Regeneration
Mathews, J., Chang, J., Devlin, L., and Levin, M. (2023), Cellular Signaling Pathways as Plastic, Proto-cognitive Systems: Implications for Biomedicine, Patterns, 4: 100737
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Murugan, N. J., Vigran, H. J., Miller, K., Golding, A., Pham, Q. L., Sperry, M., Rasmussen-Ivey, C., Kane, A. W., Kaplan, D. L., and Levin, M. (2022), Acute
multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adult Xenopus laevis,
Science Advances, 8(4): abj2164
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Sperry, M. M., Murugan, N. J., and Levin, M. (2022), Studying Protista WBR and Repair Using Physarum polycephalum, in S. Blanchoud and B. Galliot (eds.), Whole-Body Regeneration: Methods in Molecular Biology, 2450: 51-67
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Minh-Thai, T. N., Samarasinghe, S., and Levin, M. (2021), A Comprehensive Conceptual and Computational Dynamics Framework for Autonomous Regeneration Systems,
Artificial Life, 27(2): 80-104
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Davidian, D., and Levin, M. (2021) Inducing Vertebrate Limb Regeneration: A Review of Past Advances and Future Outlook, Cold Spring Harbor Perspectives in Biology,
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Sousounis, K., Erdogan, B., Levin, M., and Whited, J. L. (2020), Precise control of
ion channel and gap junction expression is required for patterning of the regenerating axolotl limb, International Journal of Developmental Biology, 64(10-11-12): 485-494
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Bischof, J., Day, M., Miller, K., LaPalme, J., and Levin, M. (2020),
Nervous System and Tissue Polarity Dynamically Adapt to New Morphologies in Planaria,
Developmental Biology, 467 (1-2): 51-65
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Leigh, N. D., Sessa, S., Dragalzew, A. C., Payzin‐Dogru, D., Sousa, J. F., Aggouras, A. N.,
Johnson, K., Dunlap, G. S., Haas, B. J., Levin, M., Schneider, I., Whited, J. L. (2020), von Willebrand factor D and EGF domains is an evolutionarily conserved and required feature of blastemas capable of multitissue appendage regeneration, Evolution & Development, 22(4): 297-311
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Sousounis, K., Bryant, D. M., Fernandez, J. M., Eddy, S. S., Tsai, S. L., Gundberg, G. C., Han, J., Courtemanche, K., Levin, M., and Whited, J. L. (2020), Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration, eLIFE, 9: e51217
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Fields, C., and Levin, M. (2020), Does regeneration recapitulate phylogeny?, Communicative & Integrative Biology, 13(1): 27-38
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Pietak, A., Bischof, J., LaPalme, J., Morokuma, J., and Levin, M. (2019), Neural control of body-plan axis in regenerating planaria,
PLOS Computational Biology, 15(4): e1006904
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Herrera-Rincon, C., Golding, A. S., Moran, K. M., Harrison, C., Martyniuk, C. J., Guay, J. A., Zaltsman, J.,
Carabello, H., Kaplan, D. L., and Levin, M. (2018), Brief Local Application of Progesterone via a Wearable
Bioreactor Induces Long-Term Regenerative Response in Adult Xenopus Hindlimb, Cell Reports, 25(6): 1593-1609
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Cairns, D. M., Giordano, J. E., Conte, S., Levin, M., and Kaplan, D. L. (2018),
Ivermectin promotes peripheral nerve regeneration during wound healing,
ACS Omega, 3(10): 12392-12402
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Busse, S. M., McMillen, P. T., and Levin, M. (2018), Cross-limb Communication During Xenopus Hind-limb Regenerative Response: Non-Local Bioelectric Injury Signals,
Development, 145(19): dev164210
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McLaughlin, K. A., and Levin, M. (2017), Bioelectric Signaling in Regeneration:
Mechanisms of Ionic Controls of Growth and Form, Developmental Biology, 433(2): 177-189
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Bryant, D. M., Sousounis, K., Farkas, J. E., Bryant, S., Thao, N., Guzikowski, A. R., Monaghan, J. R.,
Levin, M., and Whited, J. L. (2017), Repeated removal of developing limb buds permanently
reduces appendage size in the highly-regenerative axolotl, Developmental Biology, 424(1): 1-9
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Durant, F., Morokuma, J., Fields, C., Williams, K., Adams, D. S., and Levin, M. (2017),
Long-Term, Stochastic Editing of Regenerative Anatomy via Targeting Endogenous
Bioelectric Gradients, Biophysical Journal, 112(10): 2231-2243
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Garcia-Quismondo, M., Levin, M., and Lobo, D. (2017), Modeling regenerative processes with
Membrane Computing, Information Sciences, 381: 229-249
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Lobo, D., and Levin, M. (2017), Computing a worm: reverse-engineering planarian regeneration, in Adamatzky, A. (Ed), Advances in Unconventional Computing. Emergence, Complexity and Computation, vol 23, Springer: Cham, pp. 637-654
De, Abhishek, Chakravarthy, V. S., and Levin, M. (2017), A Computational Model of Planarian Regeneration, International Journal of Parallel, Emergent, and Distributed Systems, 32(4): 331-347
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Neuhof, M., Levin, M., and Rechavi, O. (2016), Vertically and horizontally-transmitted memories - the fading boundaries between regeneration and inheritance in planaria, Biology Open, 5(9): 1177-1188
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Ferreira, G. B. S., Smiley, M., Scheutz, M., and Levin, M. (2016), Dynamic structure discovery and repair for 3D cell assemblages, Proceedings of the Fifteenth International Conference on the Synthesis and Simulation of Living Systems (ALIFEXV), p. 352-359
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Serlin, Z., Rife, J., and Levin, M. (2016), A Level Set Approach to Simulating Xenopus laevis Tail Regeneration, Proceedings of the Fifteenth International Conference on the Synthesis and Simulation of Living Systems (ALIFEXV), p. 528-535
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Pietak, A., and Levin, M. (2016), Exploring Instructive Physiological Signaling with
the Bioelectric Tissue Simulation Engine , Frontiers in Bioengineering and Biotechnology, 4: 55
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Pai, V. P., Martyniuk, C. J., Echeverri, K., Sundelacruz, S., Kaplan, D. L., and Levin, M. (2016), Genome-wide analysis reveals conserved transcriptional responses downstream of resting potential change in Xenopus embryos, axolotl regeneration, and human mesenchymal cell differentiation, Regeneration, 3(1): 3-25
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Golding, A., Guay, J. A., Herrera-Rincon, C., Levin, M., and Kaplan, D. L. (2016), A Tunable Silk Hydrogel Device for Studying Limb Regeneration in Adult Xenopus laevis, PLoS One, 11(6): e0155618
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Sullivan, K. G., Emmons-Bell, M., and Levin, M. (2016), Physiological Inputs Regulate
Species-Specific Anatomy During Embryogenesis And Regeneration, Communicative & Integrative Biology, 9(4): e1192733
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Lobo, D., Morokuma, J., and Levin, M. (2016), Computational discovery and in vivo validation of hnf4 as a regulatory gene in planarian re-generation, Bioinformatics, 32(17): 2681-2685
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Durant, F., Lobo, D., Hammelman, J., and Levin, M. (2016), Physiological controls of
large-scale patterning in planarian regeneration: a molecular and computational
perspective on growth and form, Regeneration, 3(2): 78-102
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Hammelman, J., Lobo, D., and Levin, M. (2016), Artificial neural networks as models of robustness in development and regeneration: stability of memory during morphological remodeling, in S. Shanmuganathan and S. Samarasinghe (Eds.), Artificial Neural Network (ANN) Modeling. Studies in Computational Intelligence, vol. 628, pp. 45-65
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Emmons-Bell, M., Durant, F., Hammelman, J., Bessonov, N., Volpert, V., Morokuma, J., Pinet, K., Adams, D. S., Pietak, A., Lobo, D., and Levin, M. (2015), Gap junctional blockade stochastically induces different species-specific head anatomies in genetically wild-type Girardia
dorotocephala flatworms, International Journal of Molecular Sciences, 16(11): 27865-27896
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Pezzulo, G., and Levin, M. (2015), Re-membering the body: applications of computational
neuroscience to the top-down control of regeneration of limbs and other complex organs,
Integrative Biology, 7(12): 1487-1517
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Bessonov, N., Levin, M., Morozova, N., Reinberg, N., Tosenberger, A., and Volpert, V. (2015),
Target morphology and cell memory: a model of regenerative pattern formation,
Neural Regeneration Research, 10(12): 1901-1905
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Blackiston, D. J., Shomrat, T., and Levin, M. (2015), The Stability of Memories
During Brain Remodeling: a Perspective, Communicative & Integrative Biology, 8(5): e1073424
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Lobo, D., and Levin, M. (2015), Inferring regulatory networks from experimental morphological phenotypes:
a computational method reverse-engineers planarian regeneration, PLoS Computational Biology, 11(6): e1004295
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Tosenberger, A., Bessonov, N., Levin, M., Reinberg, N., Volpert, V., and Morozova, N. (2015),
A conceptual model of morphogenesis and regeneration, Acta Biotheoretica, 63(3): 283-294
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Friston, K., Levin, M., Sengupta, B., and Pezzulo, G. (2015), Knowing one's place: a free energy approach to pattern regulation, Journal of the Royal Society Interface, 12(105): 20141383
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Lobo, D., Feldman, E. B., Shah, M., Malone, T. J., and Levin,
M. (2014), Limbform: a functional ontology-based
database of limb regeneration experiments,
Bioinformatics, 30(24): 3598-3600
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Lobo, D., Feldman, E. B., Shah, M., Malone, T., and Levin, M. (2014),
A bioinformatics expert system linking functional data to
anatomical outcomes in limb regeneration, Regeneration,
1(2): 37-56
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Levin, M. (2014), Endogenous bioelectrical networks store non-genetic patterning information during development and regeneration, Journal of Physiology, 592(11): 2295-2305
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Lobo, D., Solano, M., Bubenik, G. A., and Levin, M. (2014), A linear-encoding model
explains the variability of the target morphology in regeneration,
Journal of the Royal Society Interface, 11(92): 20130918
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Lobo, D., Malone, T. J., and Levin, M. (2013), Planform: an application and database of graph-encoded planarian regenerative experiments, Bioinformatics, 29(8): 1098-1100
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Adams, D. S., Tseng, A-S. and Levin, M. (2013), Light-activation of the Archaerhodopsin
H+ pump reverses age-dependent loss of vertebrate regeneration: sparking system-level
controls in vivo, Biology Open, 2(3): 306-313
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Beane, W. S., Morokuma, J., Lemire, J. M., and Levin, M. (2013),
Bioelectric signaling regulates head and organ size during planarian regeneration,
Development, 140(2): 313-322
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Tseng, A-S., and Levin, M. (2012), Transducing bioelectrical signals into
epigenetic pathways during tadpole tail regeneration,
Anatomical Record, 295(10): 1541-1551
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Levin, M. (2012), Morphogenetic fields in embryogenesis, regeneration, and cancer:
non-local control of complex patterning, BioSystems, 109(3): 243-261
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Beane, W. S., Tseng, A-S., Morokuma, J. M., Lemire, J. M., and
Levin, M. (2012), Inhibition of
planar cell polarity extends neural growth during regeneration, homeostasis,
and development, Stem Cells and Development, 21(12):
2085-2094
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Lobo, D., Beane, W., and Levin, M. (2012), Modeling planarian
regeneration: a primer for reverse-engineering the worm,
PLoS Computational Biology, 8(4): e1002481
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Beane, W. S., Morokuma, J., Adams, D. S., and Levin, M. (2011),
A chemical genetics approach reveals H,K-ATPase-mediated
membrane voltage is required for planarian head regeneration,
Chemistry & Biology,
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Tseng, A-S., Beane, W. S., Lemire, J. M., Masi, A., and Levin, M. (2010),
Induction of vertebrate regeneration by a
transient sodium current, Journal of Neuroscience,
30(39): 13192-13200
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Hechavarria, D., Dewilde, A., Braunhut, S., Levin, M., and Kaplan, D. K. (2010), BioDome regenerative sleeve for biochemical and biophysical stimulation of tissue regeneration,
Medical Engineering and Physics, 32(9): 1065-1073
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Levin, M. (2009), Bioelectric mechanisms in regeneration: Unique aspects and future perspectives, Seminars in Cell and Developmental Biology, 20(5): 543-556
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Levin, M. (2009), Errors of Geometry: regeneration in a broader perspective, Seminars in Cell and Developmental Biology, 20(6): 643-645
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Levin, M. (2009), Regeneration: recent advances, major puzzles, and biomedical opportunities, Seminars in Cell and Developmental Biology, 20(5): 515-516
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Oviedo, N. J., Pearson, B. J., Levin, M., and Alvarado, A. S. (2008), Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling, Disease Models and Mechanisms, 1(2-3): 131-143
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Oviedo, N., and Levin, M. (2008), The planarian regeneration model as a context for the study of drug effects and mechanisms, in R. B. Raffa & S.M. Rawls (Eds.), Planaria: A Model for Drug Action and Abuse, RG Landes Co.: Austin, pp. 95-104
Oviedo, N., Nicolas, C. L., Adams, D. S., and Levin, M. (2008),Planarians: a versatile and powerful model system for molecular
studies of regeneration, adult stem cell regulation, aging, and behavior, in Emerging Model Organisms: A Laboratory Manual, Volume 1, Cold Spring Harbor Press: Cold Spring Harbor, NY
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Tseng, A-S., and Levin, M. (2008), Tail regeneration in Xenopus laevis as a model for understanding tissue repair,
Journal of Dental Research, 87(9): 806-816
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Tseng, A-S., Adams, D. S., Qiu, D., Koustubhan, P., and Levin, M. (2007), Apoptosis is required during early stages of tail regeneration in Xenopus laevis, Developmental Biology, 301(1): 62-69
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Adams, D. S., Masi, A., and Levin, M. (2007), H+ Pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration, Development, 134(7): 1323-1335
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Oviedo, N. J., and Levin, M. (2007), smedxin-11 is a Planarian Stem Cell Gap Junction Gene Required for Regeneration and Homeostasis, Development, 134(17): 3121-3131
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Levin, M. (2007), Large-Scale Biophysics: Ion Flows and Regeneration, Trends in Cell Biology, 17(6): 261-270
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Ingber, D., and Levin, M. (2007), What lies at the interface of regenerative medicine and developmental biology? Development, 134(14): 2541-2547
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