Peer-Reviewed Papers
Of Special Note
Tung, A., Sperry, M., Clawson, W., Pavuluri, A., Bulatao, S., Yue, M., Flores, R. M., Pai, V. McMillen, P., Kuchling, F., and Levin, M. (2024), Embryos assist morphogenesis of others through calcium and ATP signaling mechanisms in collective teratogen resistance, Nature Communications, 15(1): 535
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Gumuskaya, G., Srivastava, P., Cooper, B. G., Lesser, H., Semegran, B., Garnier, S., and Levin, M. (2023), Motile Living Biobots Self-Construct from Adult Human Somatic Progenitor Seed Cells, Advanced Science, doi:10.1002/advs.202303575
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Lagasse, E., and Levin, M. (2023), Future Medicine: from molecular pathways to the collective intelligence of the body, Trends in Molecular Medicine, 29(9): 687-710
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Levin, M. (2023), Bioelectric networks: the cognitive glue enabling evolutionary scaling from physiology to mind, Animal Cognition, doi:10.1007/s10071-023-01780-3
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Mathews, J., Chang, J., Devlin, L., and Levin, M. (2023), Cellular Signaling Pathways as Plastic, Proto-cognitive Systems: Implications for Biomedicine, Patterns, 4: 100737
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Blackiston, D., Kriegman, S., Bongard, J., and Levin, M. (2023), Biological Robots: Perspectives on an Emerging Interdisciplinary Field, Soft Robotics, 10(4): 694-686
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Davies, J., and Levin, M. (2023), Synthetic morphology with agential materials, Nature Reviews Bioengineering, 1(1): 46-59
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Biswas, S., Clawson, W., and Levin. M. (2023), Learning in Transcriptional Network Models: Computational Discovery of Pathway-level Memory and Effective Interventions, International Journal of Molecular Sciences, 24(1): 285
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Pai, V. P., and Levin, M. (2022), HCN2 Channel-induced Rescue of Brain, Eye, Heart, and Gut Teratogenesis Caused by Nicotine, Ethanol, and Aberrant Notch Signaling, Wound Repair and Regeneration, 30(6): 681-706
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Levin, M., and Yuste, R. (2022), Modular cognition,
Aeon Essays
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Murugan, N. J., Vigran, H. J., Miller, K., Golding, A., Pham, Q. L., Sperry, M., Rasmussen-Ivey, C., Kane, A. W., Kaplan, D. L., and Levin, M. (2022), Acute
multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adult Xenopus laevis,
Science Advances, 8(4): abj2164
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Murugan, N., Kaltman, D., Jin, H., Chien, M., Flores, R., Nguyen, C., Tuzoff, D., Minabutdinov, A., Kane, A., Novak, R., Ingber, D., and Levin, M. (2021), Mechanosensation Mediates Long-Range Spatial Decision-Making in an Aneural Organism, Advanced Materials, 33(34): 2008161
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Levin, M. (2021), Life, death, and self: Fundamental questions of primitive cognition
viewed through the lens of body plasticity and synthetic organisms,
Biochemical and Biophysical Research Communications, 564: 114-133
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Levin, M. (2021), Bioelectric Signaling: Reprogrammable Circuits
Underlying Embryogenesis, Regeneration, and Cancer, Cell, 184(8): 1971-1989
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Bongard, J., and Levin, M. (2021), Living things are not (20th Century) machines:
updating mechanism metaphors in light of the modern science of machine behavior,
Frontiers in Ecology and Evolution, 9: 650726
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Levin, M., and Dennett, D. C. (2020), How to understand cells, tissues and organisms as agents with agendas, Aeon Essays
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Kriegman, S., Blackiston, D., Levin, M., and Bongard, J. (2020), A scalable pipeline for designing reconfigurable organisms, Proceedings of the National Academy of Sciences of the United States, 432(2): 605-620
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Levin, M. (2019), The Computational Boundary of a 'Self': Developmental Bioelectricity
Drives Multicellularity and Scale-Free Cognition, Frontiers in Psychology, 10: 2688
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Emmons-Bell, M., Durant, F., Tung, A., Pietak, A., Miller, K., Kane, A., Martyniuk, C. J.,
Davidian, D., Morokuma, J., and Levin, M. (2019),
Regenerative Adaptation To Electrochemical Perturbation In Planaria: A Molecular Analysis
Of Physiological Plasticity, iScience, 22: 147-165
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Atsuta, Y., Tomizwa, R. R., Levin, M., and Tabin, C. J. (2019), L-type voltage-gated Ca2+
channel CaV1.2 regulates chondrogenesis during limb development, Proceedings of the National Academy
of Sciences of the United States, 116(43): 21592-21601
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Pietak, A., Bischof, J., LaPalme, J., Morokuma, J., and Levin, M. (2019), Neural control of body-plan axis in regenerating planaria,
PLOS Computational Biology, 15(4): e1006904
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Durant, F., Bischof, J., Fields, C., Morokuma, J., LaPalme, J., Hoi, A., and Levin, M. (2019),
The role of early bioelectric signals in the regeneration of planarian anterior/posterior polarity, Biophysical Journal, 116(5): 948-961
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Herrera-Rincon, C., Golding, A. S., Moran, K. M., Harrison, C., Martyniuk, C. J., Guay, J. A., Zaltsman, J.,
Carabello, H., Kaplan, D. L., and Levin, M. (2018), Brief Local Application of Progesterone via a Wearable
Bioreactor Induces Long-Term Regenerative Response in Adult Xenopus Hindlimb, Cell Reports, 25(6): 1593-1609
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Busse, S. M., McMillen, P. T., and Levin, M. (2018), Cross-limb Communication During Xenopus Hind-limb Regenerative Response: Non-Local Bioelectric Injury Signals,
Development, 145(19): dev164210
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Pai, V. P., Pietak, A., Willocq, V., Ye, B., Shi, N-Q., and Levin, M. (2018),
HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns,
Nature Communications, 9(1): 998
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Pietak, A. M., and Levin, M. (2017), Bioelectric Gene and Reaction Networks: Computational Modeling of Genetic, Biochemical, and Bioelectrical Dynamics in Pattern Regulation, Journal of the Royal Society Interface, 14(134): 20170425
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Herrera-Rincon, C., Pai, V. P., Moran, K. M., Lemire, J. M., and Levin, M. (2017),
The brain is required for normal muscle and nerve patterning during early
Xenopus development, Nature Communications, 8(1): 587
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Paré, J-F., Martyniuk, C. J., and Levin, M. (2017), Bioelectric regulation of innate immune system function in regenerating and intact Xenopus laevis, npj Regenerative Medicine, 2: 15
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Durant, F., Morokuma, J., Fields, C., Williams, K., Adams, D. S., and Levin, M. (2017),
Long-Term, Stochastic Editing of Regenerative Anatomy via Targeting Endogenous
Bioelectric Gradients, Biophysical Journal, 112(10): 2231-2243
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Levin, M., Pezzulo, G., and Finkelstein, J. M. (2017), Endogenous Bioelectric
Signaling Networks: Exploiting Voltage Gradients for Control of Growth and Form,
Annual Review of Biomedical Engineering, 19: 353-387
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Blackiston, D., Vien, K., and Levin, M. (2017), Serotonergic stimulation
induces nerve growth and promotes visual learning via posterior eye grafts in
a vertebrate model of induced sensory plasticity, npj Regenerative Medicine, 2:8
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Lobo, D., Lobikin, M., and Levin, M. (2017), Discovering novel phenotypes with automatically
inferred dynamic models: partial melanocyte conversion in Xenopus,
Scientific Reports, 7: 41339
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Pietak, A., and Levin, M. (2016), Exploring Instructive Physiological Signaling with
the Bioelectric Tissue Simulation Engine , Frontiers in Bioengineering and Biotechnology, 4: 55
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Baluška, F., and Levin, M. (2016), On Having No Head: Cognition throughout Biological Systems, Frontiers in Psychology, 7: 902
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Sullivan, K. G., Emmons-Bell, M., and Levin, M. (2016), Physiological Inputs Regulate
Species-Specific Anatomy During Embryogenesis And Regeneration, Communicative & Integrative Biology, 9(4): e1192733
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Durant, F., Lobo, D., Hammelman, J., and Levin, M. (2016), Physiological controls of
large-scale patterning in planarian regeneration: a molecular and computational
perspective on growth and form, Regeneration, 3(2): 78-102
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Chernet, B. T., Adams, D. S., Lobikin, M., and Levin, M. (2016),
Use of genetically encoded, light-gated ion translocators to control tumorigenesis,
Oncotarget, 7(15): 19575-19588
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Adams, D. S., Uzel, S. G. M., Akagi, J., Wlodkowic, D., Andreeva, V., Yelick, P. C., Devitt-Lee, A.,
Paré, J-F. and Levin, M. (2016), Bioelectric signaling via potassium channels: a mechanism
for craniofacial dysmorphogenesis in KCNJ2-associated Andersen-Tawil Syndrome, Journal of Physiology, 594(12): 3245-3270
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Pezzulo, G., and Levin, M. (2015), Re-membering the body: applications of computational
neuroscience to the top-down control of regeneration of limbs and other complex organs,
Integrative Biology, 7(12): 1487-1517
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Lobikin, M., Lobo, D., Blackiston, D. J., Martyniuk, C. J., Tkachenko, E., and Levin, M. (2015),
Serotonergic regulation of melanocyte conversion: A bioelectrically regulated network
for stochastic all-or-none hyperpigmentation, Science Signaling, 8(397): ra99
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Friston, K., Levin, M., Sengupta, B., and Pezzulo, G. (2015), Knowing one's place: a free energy approach to pattern regulation, Journal of the Royal Society Interface, 12(105): 20141383
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Pai, V., Lemire, J. M., Paré, J-F., Lin, G., Chen, Y., and Levin, M. (2015), Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation, Journal of Neuroscience, 35(10): 4366-4385
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Blackiston, D., Anderson, G. M., Rahman, N., Bieck, C., and Levin, M. (2015), A novel method for inducing nerve growth via modulation of host resting potential, Neurotherapeutics, 12(1): 170-184
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Levin, M. (2014), Molecular bioelectricity: how endogenous voltage potentials control cell behavior
and instruct pattern regulation in vivo, Molecular Biology of the Cell, 25(24): 3835-3850
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Chernet, B., and Levin, M. (2014), Transmembrane voltage potential of
somatic cells controls oncogene-mediated tumorigenesis at long-range,
Oncotarget, 5(10): 3287-3306
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Tseng, A-S., and Levin, M. (2013), Cracking the
bioelectric code: probing endogenous ionic controls of pattern
formation, Communicative & Integrative Biology,
6(1): e22595
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Adams, D. S., Tseng, A-S. and Levin, M. (2013), Light-activation of the Archaerhodopsin
H+ pump reverses age-dependent loss of vertebrate regeneration: sparking system-level
controls in vivo, Biology Open, 2(3): 306-313
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Lobikin, M., Wang, G., Xu, J.-S., Hsieh, Y.-W., Chuang, C.-F., Lemire, J. M., and Levin, M. (2012), Early, nonciliary role for microtubule proteins in left-right patterning is conserved across kingdoms, Proceedings of the National Academy of Sciences, 109(31): 12586-12591
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Levin, M. (2012), Morphogenetic fields in embryogenesis, regeneration, and cancer:
non-local control of complex patterning, BioSystems, 109(3): 243-261
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Levin, M. (2012), Molecular bioelectricity in developmental biology: new
tools and recent discoveries BioEssays, 34(3): 205-217
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Pai, V., Aw, S., Shomrat, T., Lemire, J. M., and Levin, M. (2012), Transmembrane
voltage potential controls embryonic eye patterning in Xenopus laevis,
Development, 139(2): 313-323
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Blackiston, D., Adams, D. S., Lemire, J. M., Lobikin, M., and Levin, M. (2011),
Transmembrane potential of GlyCl-expressing instructor cells induces a neoplastic-like conversion of
melanocytes via a serotonergic pathway, Disease Models and Mechanisms, 4(1): 67-85
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Beane, W. S., Morokuma, J., Adams, D. S., and Levin, M. (2011),
A chemical genetics approach reveals H,K-ATPase-mediated
membrane voltage is required for planarian head regeneration,
Chemistry & Biology,
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Levin, M. (2011), The wisdom of the body: future techniques and approaches to morphogenetic fields in regenerative medicine, developmental biology, and cancer, Regenerative Medicine, 6(6): 667-673
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Oviedo, N. J., Morokuma, J., Walentek, P., Kema, I. P., Gu, M. B., Ahn, J. M., Hwang, J. S., Gojobori, T., and Levin, M. (2010), Long-range Neural and Gap Junction Protein-mediated Cues Control Polarity During Planarian Regeneration, Developmental Biology, 339(1): 188-199
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Tseng, A-S., Beane, W. S., Lemire, J. M., Masi, A., and Levin, M. (2010),
Induction of vertebrate regeneration by a transient sodium current,
Journal of Neuroscience, 30(39): 13192-13200
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Vandenberg, L. N., and Levin, M. (2010), Far from solved: a perspective on what we know about early mechanisms of left-right asymmetry, Developmental Dynamics, 239(12): 3131-3146
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Aw, S., and Levin, M. (2009), Is left-right asymmetry a form of planar cell polarity? Development, 136(3): 355-366
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Levin, M. (2009), Bioelectric mechanisms in regeneration: Unique aspects and future perspectives, Seminars in Cell and Developmental Biology, 20(5): 543-556
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Levin, M. (2007), Large-Scale Biophysics: Ion Flows and Regeneration, Trends in Cell Biology, 17(6): 261-270
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Levin, M., Thorlin, T., Robinson, K., Nogi, T., and Mercola, M. (2002),
Asymmetries in H+/K+-ATPase and cell membrane potentials comprise
a very early step in left-right patterning,
Cell, 111(1): 77-89
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Levin, M., and Nascone, N. (1997), Two molecular models of initial left-right asymmetry generation,
Medical Hypotheses, 49(5): 429-435
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Levin, M., Johnson, R. L., Stern, C. D., Kuehn, M., and Tabin, C. (1995), A molecular pathway determining left-right asymmetry in chick embryogenesis, Cell, 82(5): 803-814
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